benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate
CAS No.:898264-62-5
Molecular Formula:C₃₂H₅₀N₄O₇
Molecular Weight:602.772
Hs Code.:

benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Synonyms:benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate

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Chemical Property of benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate

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Technology Process of benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate

There total 10 articles about benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 898264-61-4
methyl (5S,8S,11S)-5-((R)-1-(tert-butoxy)ethyl)-8-(cyclohexylmethyl)-3,6,9-trioxo-11-(((S)-2-oxopyrrolidin-3-yl)methyl)-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oate

: 898264-62-5
benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm0603926

Reference yield:

: 59279-60-6,130622-05-8,861658-15-3
dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

: 898264-62-5
benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: LiHMDS / tetrahydrofuran / 1.5 h / -78 °C

1.2: 83 percent / tetrahydrofuran / -78 °C

2.1: H₂ / Pd/C / 2 h / 3620.04 Torr

3.1: 5.55 g / Et₃N / tetrahydrofuran / 60 °C

4.1: HCl / dioxane / 0.5 h / 20 °C

5.1: 0.576 g / EDC; HOBt / CH₂Cl₂ / 2 h / 20 °C

6.1: HCl / dioxane / 0.5 h / 20 °C

7.1: 0.408 g / EDC; HOBt / CH₂Cl₂ / 2 h / 20 °C

8.1: 74 percent / LiBH₄ / tetrahydrofuran / 2 h / 0 - 20 °C

With hydrogenchloride; lithium borohydride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm0603926

Reference yield:

: 328086-57-3
(2S,4S)-2-tert-butoxycarbonylamino-4-cyanomethyl-pentadioic acid dimethyl ester

: 898264-62-5
benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Pd/C / 2 h / 3620.04 Torr

2: 5.55 g / Et₃N / tetrahydrofuran / 60 °C

3: HCl / dioxane / 0.5 h / 20 °C

4: 0.576 g / EDC; HOBt / CH₂Cl₂ / 2 h / 20 °C

5: HCl / dioxane / 0.5 h / 20 °C

6: 0.408 g / EDC; HOBt / CH₂Cl₂ / 2 h / 20 °C

7: 74 percent / LiBH₄ / tetrahydrofuran / 2 h / 0 - 20 °C

With hydrogenchloride; lithium borohydride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm0603926