(R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride

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Chemical Name:(R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride
CAS No.:123004-77-3
Molecular Formula:C₃₆H₅₀N₄O₁₀*ClH
Molecular Weight:735.275
Hs Code.:

(R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride

Synonyms:(R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride

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Chemical Property of (R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride

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Technology Process of (R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride

There total 10 articles about (R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 123004-76-2
(R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester

: 123004-77-3
(R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 2068.6 Torr;
DOI:10.1021/ja00158a040

Reference yield:

: 123004-74-0
tert-butyl D-2-<(tert-butoxycarbonyl)amino>-4-bromobutyrate

: 123004-77-3
(R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) potassium hydride / 1.) DMF, RT, 10 min, 2.) RT, 3 h

2: 88 percent / 2,6-lutidine, 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) RT, 1.5 h

3: 98 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 2068.6 Torr

With 2,6-dimethylpyridine; hydrogen; potassium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/ja00158a040

Reference yield:

: 110207-49-3
tert-butyl D-N-(tert-butoxycarbonyl)homoserinate

: 123004-77-3
(R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / carbon tetrabromide, triphenylphosphine / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) potassium hydride / 1.) DMF, RT, 10 min, 2.) RT, 3 h

3: 88 percent / 2,6-lutidine, 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) RT, 1.5 h

4: 98 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 2068.6 Torr

With 2,6-dimethylpyridine; carbon tetrabromide; hydrogen; potassium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja00158a040