(-)-(1R,2S,2'R,3'S)-2-phenylcyclohexyl 2'-benzyl-2',3'-dihydroxy-3'-phenylpropanoate

Base Information

Chemical Name:(-)-(1R,2S,2'R,3'S)-2-phenylcyclohexyl 2'-benzyl-2',3'-dihydroxy-3'-phenylpropanoate
CAS No.:1187159-08-5
Molecular Formula:C₂₈H₃₀O₄
Molecular Weight:430.544
Hs Code.:

Synonyms:(-)-(1R,2S,2'R,3'S)-2-phenylcyclohexyl 2'-benzyl-2',3'-dihydroxy-3'-phenylpropanoate

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Chemical Property of (-)-(1R,2S,2'R,3'S)-2-phenylcyclohexyl 2'-benzyl-2',3'-dihydroxy-3'-phenylpropanoate

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Technology Process of (-)-(1R,2S,2'R,3'S)-2-phenylcyclohexyl 2'-benzyl-2',3'-dihydroxy-3'-phenylpropanoate

There total 1 articles about (-)-(1R,2S,2'R,3'S)-2-phenylcyclohexyl 2'-benzyl-2',3'-dihydroxy-3'-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 100-52-7
benzaldehyde

: 152533-28-3
(-)-(1R,2S)-2-phenylcyclohexyl 2'-(benzyloxy)acetate

: 1187159-08-5
(-)-(1R,2S,2'R,3'S)-2-phenylcyclohexyl 2'-benzyl-2',3'-dihydroxy-3'-phenylpropanoate

Guidance literature:: (-)-(1R,2S)-2-phenylcyclohexyl 2'-(benzyloxy)acetate; With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

benzaldehyde; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With dihydrogen peroxide; In methanol; dichloromethane; water; at 0 - 20 ℃; optical yield given as %de; diastereoselective reaction; aq. buffer;
DOI:10.1021/ja905930s

Reference yield: 90.0%

: 1187159-08-5
(-)-(1R,2S,2'R,3'S)-2-phenylcyclohexyl 2'-benzyl-2',3'-dihydroxy-3'-phenylpropanoate

: 77-76-9
2,2-dimethoxy-propane

: 1187159-41-6
(1R,2S,4'R,5'S)-2-phenylcyclohexyl 4'-benzyl-2',2'-dimethyl-5'-phenyl-1',3'-dioxolane-4'-carboxylate

Guidance literature:: With camphor-10-sulfonic acid; In acetone; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja905930s

Reference yield:

: 1187159-08-5
(-)-(1R,2S,2'R,3'S)-2-phenylcyclohexyl 2'-benzyl-2',3'-dihydroxy-3'-phenylpropanoate

: (-)-(1R,2R)-2-benzyl-1-phenylpropane-1,2,3-triol

: 1187159-10-9
(+)-(1S,2S)-2-benzyl-1-phenylpropane-1,2,3-triol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/ja905930s