3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>-17-(3-pyridyl)androsta-3,5,16-triene

Base Information

Chemical Name:3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>-17-(3-pyridyl)androsta-3,5,16-triene
CAS No.:154229-38-6
Molecular Formula:C₃₁H₂₈F₇NO
Molecular Weight:563.558
Hs Code.:

Synonyms:3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>-17-(3-pyridyl)androsta-3,5,16-triene

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Chemical Property of 3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>-17-(3-pyridyl)androsta-3,5,16-triene

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Technology Process of 3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>-17-(3-pyridyl)androsta-3,5,16-triene

There total 3 articles about 3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>-17-(3-pyridyl)androsta-3,5,16-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

petroleum-diethyl ether: petroleum-diethyl ether

: 497-19-8
sodium carbonate

: 89878-14-8
3-Diethylboranylpyridine

: 154229-37-5
3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>androsta-3,5,16-trien-17-yl trifluoromethanesulfonate

: 154229-38-6
3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>-17-(3-pyridyl)androsta-3,5,16-triene

Guidance literature:: bis(triphenylphosphine)palladium(II)-chloride; In tetrahydrofuran;

Reference yield: 73.0%

: 89878-14-8
3-Diethylboranylpyridine

: 154229-37-5
3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>androsta-3,5,16-trien-17-yl trifluoromethanesulfonate

: 154229-38-6
3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>-17-(3-pyridyl)androsta-3,5,16-triene

Guidance literature:: With bis(triphenylphosphine)palladium(II)-chloride; sodium carbonate; In tetrahydrofuran; at 80 ℃; for 1h;
DOI:10.1021/jm00013a022

Reference yield:

: 103708-01-6
3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>androsta-3,4-diene-17-one

: 154229-38-6
3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>-17-(3-pyridyl)androsta-3,5,16-triene

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / 12 h

2: 73 percent / bis(triphenylphosphine)palladium(II) chloride, aq. Na₂CO₃ / tetrahydrofuran / 1 h / 80 °C

With 2,6-di-tert-butyl-4-methylpyridine; bis(triphenylphosphine)palladium(II)-chloride; sodium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00013a022