Imidazole hydrochloride

Base Information

• Chemical Name: Imidazole hydrochloride
• CAS No.: 1467-16-9
• Molecular Formula: C3H4N2.ClH
• Molecular Weight: 104.539
• Hs Code.: 2933290090
• European Community (EC) Number: 604-535-6
• UNII: 52C2DIA291
• DSSTox Substance ID: DTXSID80932890
• Wikidata: Q27260997
• Mol file: 1467-16-9.mol

Synonyms:Al-imidazole;Cu-imidazole;imidazole;imidazole acetate;imidazole citrate;imidazole conjugate monoacid;imidazole monohydrochloride;imidazole monophosphonate;imidazole sodium;imidazolium chloride

Chemical Property of Imidazole hydrochloride

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 0.024mmHg at 25°C
• Melting Point: 158-161 °C(lit.)
• Boiling Point: 257 °C at 760 mmHg
• Flash Point: 145 °C
• PSA: 28.68000
• LogP: 1.21170
• Storage Temp.: Store at RT.
• Solubility.: H2O: 50 mg/mL, clear, colorless
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 104.0141259
• Heavy Atom Count: 6
• Complexity: 28.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

Imidazole hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Imidazoles
• Canonical SMILES: C1=CN=CN1.Cl
• Uses: Imidazole hydrochloride is a useful research chemical. Imidazole hydrochloride has been used:in double immunohistochemistryto determine the activity of octopine dehydrogenase (ODH) in Mytilus galloprovincialisto study the cytoskeletal features during in vitro fertilization after intracytoplasmic sperm injection (ICSI) among humansas a reagent in the synthesis of a probe for monitoring herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene expression in rodents

Technology Process of Imidazole hydrochloride

There total 13 articles about Imidazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1H-imidazole (288-32-4) → Imidazole hydrochloride (1467-16-9)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1002/anie.201100199

Reference yield: 99.0%

tert-butyl 1H-imidazole-1-carboxylate (49761-82-2) → Imidazole hydrochloride (1467-16-9)

Guidance literature:

With sulfuric acid; sodium chloride; In neat (no solvent); at 20 ℃; for 1h; Sealed tube;

DOI:10.1039/d1ob00728a

Reference yield: 94.0%

1H-imidazole (288-32-4) + tert-butyldimethylsilyl chloride (18162-48-6) + 4-methoxy-phenol (150-76-5) → 4-(tert-butyldimethylsilyloxy)anisole (62790-87-8) + Imidazole hydrochloride (1467-16-9)

Guidance literature:

In neat (no solvent, solid phase); at 20 ℃; for 0.00416667h; Flow reactor; Green chemistry;

DOI:10.1039/c9gc02447f

upstream raw materials:

1H-imidazole

N,N-Dimethylcarbamoyl chloride

phosgene

trichloromethyl chloroformate

Downstream raw materials:

imidazole Salicylate

1-benzylimidazole

C₃H₄N₂*C₁₂H₇N₉O₁₂

1H-imidazole

Refernces

• 1、 Aryafard, Meysam,Minofar, Babak,Cséfalvay, Eva,Malinová, Lenka,?eha, David. "Novel room temperature ionic liquids and low melting mixtures based on imidazolium: Cheap ionic solvents for chemical and biological applications". . . Retrieved 2021/11/09.
• 2、 Sharma, Brijesh M.,Atapalkar, Ranjit S.,Kulkarni, Amol A.. "Continuous flow solvent free organic synthesis involving solids (reactants/products) using a screw reactor". supporting information. p. 5639 - 5646. Retrieved 2019/10/22.