2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

Base Information

• Chemical Name: 2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide
• CAS No.: 1093987-89-3
• Molecular Formula: C₁₅H₁₀Cl₂FN₃O₂
• Molecular Weight: 354.168
• Mol file: 1093987-89-3.mol

Synonyms:2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

Chemical Property of 2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

There total 8 articles about 2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester (867366-78-7) → 2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide (1093987-89-3)

Guidance literature:

With hydrazine; In ethanol; for 2h; Reflux;

Reference yield:

3,5-dichlorobenzonitrile (6575-00-4) → 2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide (1093987-89-3)

Guidance literature:

Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide / 0 °C

1.2: Cooling with ice

2.1: 2,4,6-trimethyl-pyridine; lithium iodide / 8 h / 185 °C / Inert atmosphere

2.2: Cooling with ice

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

4.2: 4 h / 0 - 20 °C

4.3: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

5.2: 0 °C

6.1: sodium dithionite / tetrahydrofuran; water / 1 h / 20 °C

7.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C

8.1: hydrazine / ethanol / 2 h / Reflux

With 2,4,6-trimethyl-pyridine; tert.-butylnitrite; sodium dithionite; sodium hydride; trifluoroacetic acid; copper dichloride; lithium iodide; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

3-chloro-5-hydroxybenzonitrile (473923-97-6) → 2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide (1093987-89-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 4 h / 0 - 20 °C

2.3: 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

3.2: 0 °C

4.1: sodium dithionite / tetrahydrofuran; water / 1 h / 20 °C

5.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C

6.1: hydrazine / ethanol / 2 h / Reflux

With tert.-butylnitrite; sodium dithionite; sodium hydride; trifluoroacetic acid; copper dichloride; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; mineral oil;

upstream raw materials:

3,5-dichlorobenzonitrile

3-chloro-5-methoxybenzonitrile

3-chloro-5-hydroxybenzonitrile

3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile

Downstream raw materials:

3-chloro-5-[(6-chloro-3-{[5-(3,5-dimethyl-1H-pyrrol-2-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile

3-chloro-5-(6-chloro-2-fluoro-3-((5-(3-methyl-1H-pyrrol-2-yl)-1,3,4-oxadiazol-2-yl)methyl)phenoxy)benzonitrile

3-chloro-5-({6-chloro-3-[(5-{3,5-dimethyl-1-[2-(methylsulfonyl)ethyl]-1H-pyrazol-4-yl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile

3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-1,3-thiazol-5-yl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile