867366-78-7

Upstream product

• 770719-10-3 [3-(3-chloro-5-cyanophenoxy)-2-fluoro-4-nitrophenyl]acetic acid ethyl ester 
• 867367-05-3 1,1-dimethylethyl ethyl {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl} propanedioate 
• 770719-09-0 3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile 
• 473923-97-6 3-chloro-5-hydroxybenzonitrile 
• 473923-96-5 3-chloro-5-methoxybenzonitrile 
• 6575-00-4 3,5-dichlorobenzonitrile 
• 770719-11-4 ethyl {4-amino-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetate 

Downstream Products

• 1094342-13-8 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 
• 1094342-18-3 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(1-methyl-1H-imidazol-2-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 
• 1094342-72-9 3-chloro-5-(6-chloro-3-((5-(4-chloro-2-ethyl-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl)methyl)-2-fluorophenoxy)benzonitrile 
• 1094344-90-7 3-chloro-5-(6-chloro-3-((5-(5-chloro-1-(2-chlorobenzyl)-3-methyl-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl)methyl)-2-fluorophenoxy)benzonitrile 
• 1094345-11-5 3-chloro-5-(6-chloro-3-((5-(3,4-dichlorofuran-2-yl)-1,3,4-oxadiazol-2-yl)methyl)-2-fluorophenoxy)benzonitrile 
• 1094345-21-7 3-chloro-5-(6-chloro-2-fluoro-3-((5-(4-methyl-2-(pyridin-4-yl)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl)methyl)phenoxy)benzonitrile 
• 1094345-29-5 3-chloro-5-(6-chloro-2-fluoro-3-((5-(3-methyl-1H-pyrrol-2-yl)-1,3,4-oxadiazol-2-yl)methyl)phenoxy)benzonitrile 
• 1094345-35-3 3-chloro-5-(6-chloro-2-fluoro-3-((5-(5-methyl-1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazol-2-yl)methyl)phenoxy)benzonitrile 
• 1094345-45-5 3-chloro-5-({6-chloro-3-[(5-{3,5-dimethyl-1-[2-(methylsulfonyl)ethyl]-1H-pyrazol-4-yl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile 
• 1094347-72-4 3-chloro-5-[(6-chloro-3-{[5-(3,5-dimethyl-1-{[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 
• 1094345-49-9 3-chloro-5-({6-chloro-3-[(5-{1-[(2S)-2,3-dihydroxy-3-methylbutyl]-3,5-dimethyl-1H-pyrazol-4-yl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile 
• 1094342-45-6 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[2-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 
• 1094342-48-9 3-chloro-5-[(6-chloro-3-{[5-(6-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-2-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 
• 1094342-50-3 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-1,3-thiazol-5-yl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 

Relevant academic research and scientific papers

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds of formula I, wherein R1, R2, R3, X1, X2 and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

Non-nucleoside reverse transcriptase inhibitors

The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A1, A2, A3 or A4 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.

Non-nucleoside reverse transcriptase inhibitors

The present invention provides for compounds useful for treating an HIV-1 infection, or preventing an HIV-1 infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1, R2, R3, R4, R5 and X are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds. [image]

Non-nucleoside reverse transcriptase inhibitors

The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1-R5, R7a, R7b, R7c, R8-R10, X1, X2 m, n, o and p are as defined herein.