(2S,3S)-2,3-bis(4-(trifluoromethyl)phenyl)-1,4-diazabicyclo[2.2.2]octane

Base Information

Chemical Name:(2S,3S)-2,3-bis(4-(trifluoromethyl)phenyl)-1,4-diazabicyclo[2.2.2]octane
CAS No.:1499076-43-5
Molecular Formula:CF₃O₃S*C₂₁H₂₁F₆N₂
Molecular Weight:564.472
Hs Code.:

Synonyms:(2S,3S)-2,3-bis(4-(trifluoromethyl)phenyl)-1,4-diazabicyclo[2.2.2]octane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-2,3-bis(4-(trifluoromethyl)phenyl)-1,4-diazabicyclo[2.2.2]octane

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Technology Process of (2S,3S)-2,3-bis(4-(trifluoromethyl)phenyl)-1,4-diazabicyclo[2.2.2]octane

There total 10 articles about (2S,3S)-2,3-bis(4-(trifluoromethyl)phenyl)-1,4-diazabicyclo[2.2.2]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1499076-41-3
(2S,3S)-2,3-bis(4-(trifluoromethyl)phenyl)-1,4-diazabicyclo[2.2.2]octane

: 333-27-7
methyl trifluoromethanesulfonate

: 1499076-43-5
(2S,3S)-2,3-bis(4-(trifluoromethyl)phenyl)-1,4-diazabicyclo[2.2.2]octane

Guidance literature:: In diethyl ether; at 0 ℃; for 3h;
DOI:10.1002/anie.201304845

Reference yield:

: 35132-20-8
(R,R)-1,2-diphenylethylenediamine

: 1499076-43-5
(2S,3S)-2,3-bis(4-(trifluoromethyl)phenyl)-1,4-diazabicyclo[2.2.2]octane

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine; dmap / dichloromethane / 3 h / 0 - 20 °C

2: borane-THF / tetrahydrofuran / 12 h / 0 °C / Reflux

3: N,N-dimethyl-formamide / 5 h / Reflux

4: diethyl ether / 3 h / 0 °C

5: fluorine / acetonitrile / -35 °C / Inert atmosphere

6: triethylamine; dmap / dichloromethane / 3 h / 0 - 20 °C

7: borane-THF / tetrahydrofuran / 12 h / 0 °C / Reflux

8: N,N-dimethyl-formamide / 5 h / Reflux

9: diethyl ether / 3 h / 0 °C

With dmap; borane-THF; fluorine; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201304845

Reference yield:

: C₃₀H₂₂F₆N₂O₂

: 1499076-43-5
(2S,3S)-2,3-bis(4-(trifluoromethyl)phenyl)-1,4-diazabicyclo[2.2.2]octane

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / tetrahydrofuran; water / 3 h

2: triethylamine; dmap / dichloromethane / 3 h / 0 - 20 °C

3: borane-THF / tetrahydrofuran / 12 h / 0 °C / Reflux

4: N,N-dimethyl-formamide / 5 h / Reflux

5: diethyl ether / 3 h / 0 °C

With hydrogenchloride; dmap; borane-THF; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201304845