(Z)-2-[(E)-2-(4-Fluoro-phenyl)-vinyl]-3-methyl-pent-2-enedioic acid 1-methyl ester

Base Information

Chemical Name:(Z)-2-[(E)-2-(4-Fluoro-phenyl)-vinyl]-3-methyl-pent-2-enedioic acid 1-methyl ester
CAS No.:135628-93-2
Molecular Formula:C₁₅H₁₅FO₄
Molecular Weight:278.28
Hs Code.:

Synonyms:(Z)-2-[(E)-2-(4-Fluoro-phenyl)-vinyl]-3-methyl-pent-2-enedioic acid 1-methyl ester

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Chemical Property of (Z)-2-[(E)-2-(4-Fluoro-phenyl)-vinyl]-3-methyl-pent-2-enedioic acid 1-methyl ester

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Technology Process of (Z)-2-[(E)-2-(4-Fluoro-phenyl)-vinyl]-3-methyl-pent-2-enedioic acid 1-methyl ester

There total 3 articles about (Z)-2-[(E)-2-(4-Fluoro-phenyl)-vinyl]-3-methyl-pent-2-enedioic acid 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 52313-87-8
3-methyl-2-pentene-1,5-diacid dimethyl

: 1736-67-0
4-fluorophenylacetaldehyde

: 135628-93-2
(Z)-2-[(E)-2-(4-Fluoro-phenyl)-vinyl]-3-methyl-pent-2-enedioic acid 1-methyl ester

Guidance literature:: With sodium methylate; In diethyl ether; at 20 ℃; for 2h;
DOI:10.1080/00397919108019763

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 135628-93-2
(Z)-2-[(E)-2-(4-Fluoro-phenyl)-vinyl]-3-methyl-pent-2-enedioic acid 1-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride / benzene / 3 h / Ambient temperature

2: CdCl₂*1.5 DMF, NaBH₄, HMPA / acetonitrile / 0.05 h / -5 °C

3: 60 percent / MeONa / diethyl ether / 2 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; oxalyl dichloride; sodium methylate; cadmium(II) chloride; In diethyl ether; acetonitrile; benzene;
DOI:10.1080/00397919108019763

Reference yield:

: 459-04-1
4-Fluorophenylacetyl chloride

: 135628-93-2
(Z)-2-[(E)-2-(4-Fluoro-phenyl)-vinyl]-3-methyl-pent-2-enedioic acid 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: CdCl₂*1.5 DMF, NaBH₄, HMPA / acetonitrile / 0.05 h / -5 °C

2: 60 percent / MeONa / diethyl ether / 2 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; sodium methylate; cadmium(II) chloride; In diethyl ether; acetonitrile;
DOI:10.1080/00397919108019763