2-(4-Fluorophenyl)acetaldehyde

Base Information

• Chemical Name: 2-(4-Fluorophenyl)acetaldehyde
• CAS No.: 1736-67-0
• Molecular Formula: C8H7FO
• Molecular Weight: 138.141
• Hs Code.: 2913000090
• DSSTox Substance ID: DTXSID80456061
• Nikkaji Number: J2.622.528K
• Wikidata: Q82278264
• Mol file: 1736-67-0.mol

Synonyms:2-(4-fluorophenyl)acetaldehyde;1736-67-0;(4-FLUORO-PHENYL)-ACETALDEHYDE;(4-Fluorophenyl)acetaldehyde;BENZENEACETALDEHYDE, 4-FLUORO-;4-fluorophenylacetaldehyde;Benzeneacetaldehyde,4-fluoro-;p-fluorophenylacetaldehyde;MFCD02261761;4-fluorophenyl acetaldehyde;2-(4-fluorophenyl) ethanal;SCHEMBL418183;DTXSID80456061;KCXZRESSSSYYCW-UHFFFAOYSA-N;AKOS011896309;AB11805;GS-5993;(4-Fluorophenyl)acetaldehyde, AldrichCPR;SY042926;FT-0649587;EN300-100501;H10605;A811544;J-010931;Z993017752

Chemical Property of 2-(4-Fluorophenyl)acetaldehyde

Chemical Property:

• Vapor Pressure: 0.261mmHg at 25°C
• Refractive Index: 1.493
• Boiling Point: 204.646 °C at 760 mmHg
• Flash Point: 74.552 °C
• PSA: 17.07000
• Density: 1.116 g/cm³
• LogP: 1.56710
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 138.048093005
• Heavy Atom Count: 10
• Complexity: 106

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Fluorophenyl)acetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC=O)F

Technology Process of 2-(4-Fluorophenyl)acetaldehyde

There total 30 articles about 2-(4-Fluorophenyl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-fluorostyrene oxide (18511-62-1,53631-23-5,134356-73-3,134356-74-4) + bis(1,5-cyclooctadiene)rhodium trifluoromethansulfonate → 4-fluorophenylacetaldehyde (1736-67-0)

Guidance literature:

In benzene;

Reference yield: 100.0%

4-fluorostyrene oxide (18511-62-1,53631-23-5,134356-73-3,134356-74-4) → 4-fluorophenylacetaldehyde (1736-67-0)

Guidance literature:

Reference yield: 94.0%

para-fluorostyrene (405-99-2) → 4-fluorophenylacetaldehyde (1736-67-0)

Guidance literature:

para-fluorostyrene; With ammonium iodide; water; sodium dodecyl-sulfate; for 0.5h;

With Oxone; at 20 ℃; for 0.15h; regioselective reaction;

DOI:10.1002/adsc.201400986

upstream raw materials:

4-Fluorophenylacetyl chloride

2-(4-Fluorophenyl)ethanol

para-fluorostyrene

p-Fluorophenylacetic acid

Downstream raw materials:

2-amino-5-(4-fluorophenyl)-3-thiophenecarboxamide

C₂₂H₂₄ClFN₂O

2-(4-fluorophenyl)-2-oxo-N,N'-di(p-tolyl)acetimidamide

5-fluoro-1H-inden-2(3H)-one

Refernces

• 1、 Hu, Dianwen,Song, Xiaojing,Zhang, Hao,Chang, Xinyu,Zhao, Chen,Jia, Mingjun. "Aerobic epoxidation of styrene over Zr-based metal-organic framework encapsulated transition metal substituted phosphomolybdic acid". . . Retrieved 2021/04/19.
• 2、 Li, Jie,Li, Ruoling,Yang, Wen,Zhao, Pei,Zhao, Wanxiang. "Rhodium-Catalyzed β-Dehydroborylation of Silyl Enol Ethers: Access to Highly Functionalized Enolates". supporting information. p. 9580 - 9585. Retrieved 2021/12/14.