N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolic acid

Base Information

Chemical Name:N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolic acid
CAS No.:157982-66-6
Molecular Formula:C₁₈H₂₃NO₆
Molecular Weight:349.384
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolic acid

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Chemical Property of N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolic acid

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Technology Process of N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolic acid

There total 4 articles about N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 157982-65-5
tert-butyl N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolate

: 157982-66-6
N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolic acid

Guidance literature:: With trifluoroacetic acid; for 3h; Ambient temperature;
DOI:10.1016/S0040-4039(00)73161-3

Reference yield:

: 129605-87-4
tert-Butyl N-(benzyloxycarbonyl)-2(RS)-allylpipecolate

: 157982-66-6
N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: BH₃*S(CH₃)2 / tetrahydrofuran / 3 h / 20 °C

1.2: 75 percent / hydrogen peroxide; 3 N sodium hydroxide / ethanol; H₂O

2.1: 95 percent / pyridinium dichromate / dimethylformamide / 24 h / 20 °C

3.1: 100 percent / diethyl ether

4.1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 15 h / 20 °C

With dipyridinium dichromate; dimethylsulfide borane complex; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1.1: Addition / 1.2: Substitution / 2.1: Oxidation / 3.1: Esterification / 4.1: Hydrolysis;
DOI:10.1016/S0040-4020(98)00689-9

Reference yield:

: 157982-63-3
tert-butyl N-(benzyloxycarbonyl)-2-(3-hydroxy-propyl)-pipecolate

: 157982-66-6
N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / pyridinium dichromate / dimethylformamide / 24 h / 20 °C

2: 100 percent / diethyl ether

3: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 15 h / 20 °C

With dipyridinium dichromate; trifluoroacetic acid; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Oxidation / 2: Esterification / 3: Hydrolysis;
DOI:10.1016/S0040-4020(98)00689-9