5-NITRO-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-NITRO-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 181585-93-3
• Molecular Formula: C5H5 N3 O4
• Molecular Weight: 171.112
• Hs Code.: 2933199090
• Mol file: 181585-93-3.mol

Synonyms:5-Nitro-1H-pyrazole-3-carboxylicacid methyl ester; 5-Nitro-3-pyrazolecarboxylic acid methyl ester; Methyl 5-nitro-1H-pyrazole-3-carboxylate;Methyl 5-nitropyrazole-3-carboxylate

Chemical Property of 5-NITRO-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 3.09E-06mmHg at 25°C
• Melting Point: 145.5℃
• Boiling Point: 388.3°C at 760 mmHg
• PKA: 5.36±0.10(Predicted)
• Flash Point: 188.7°C
• PSA: 100.80000
• Density: 1.545g/cm³
• LogP: 0.62770
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-Nitro-1H-pyrazole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-NITRO-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

There total 5 articles about 5-NITRO-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3-nitro-1H-pyrazole-5-carboxylic acid → 5-nitro-2H-pyrazole-3-carboxylic acid methyl ester (181585-93-3)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; at 0 - 70 ℃; for 4h;

Reference yield: 100.0%

methanol (67-56-1) + 5-nitropyrazole-3-carboxylic acid (198348-89-9) → 5-nitro-1H-pyrazole-3-carboxylic acid methyl ester (181585-93-3)

Guidance literature:

With thionyl chloride; at 0 ℃; Reflux; Inert atmosphere;

Reference yield: 95.0%

methanol (67-56-1) + 5-nitropyrazole-3-carboxylic acid (198348-89-9) → 5-nitro-2H-pyrazole-3-carboxylic acid methyl ester (181585-93-3)

Guidance literature:

With thionyl chloride; at 0 ℃; Product distribution / selectivity; Reflux;

upstream raw materials:

methanol

5-nitropyrazole-3-carboxylic acid

Downstream raw materials:

2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

methyl 3-amino-1H-pyrazole-5-carboxylate

5-nitro-2-(3,4,5-trifluoro-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester

5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester