METHYL 3-(DIMETHYLAMINO)-2-ISOCYANOACRYLATE

Base Information

• Chemical Name: METHYL 3-(DIMETHYLAMINO)-2-ISOCYANOACRYLATE
• CAS No.: 72130-98-4
• Molecular Formula: C7H10 N2 O2
• Molecular Weight: 154.17
• Mol file: 72130-98-4.mol

Synonyms:2-Propenoicacid, 3-(dimethylamino)-2-isocyano-, methyl ester, (Z)-

Chemical Property of METHYL 3-(DIMETHYLAMINO)-2-ISOCYANOACRYLATE

Chemical Property:

• Melting Point: 61 °C
• PSA: 29.54000
• LogP: -0.28760

Purity/Quality:

3-Dimethylamino-2-isocyanoacrylicacidmethylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-(DIMETHYLAMINO)-2-ISOCYANOACRYLATE

There total 3 articles about METHYL 3-(DIMETHYLAMINO)-2-ISOCYANOACRYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

isocyanoacetic acid methyl ester (39687-95-1) + dimethyl amine (124-40-3) + 1-(diethoxymethyl)-1H-imidazole (61278-81-7) → (Z)-1-(dimethylamino)-3-methoxy-N-methylidyne-3-oxoprop-1-en-2-aminium (72130-98-4)

Guidance literature:

With camphor-10-sulfonic acid; In N,N-dimethyl-formamide; at 70 - 80 ℃; Product distribution; different secondary amines;

DOI:10.1016/S0040-4039(98)00696-0

Reference yield: 64.0%

isocyanoacetic acid methyl ester (39687-95-1) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → (Z)-1-(dimethylamino)-3-methoxy-N-methylidyne-3-oxoprop-1-en-2-aminium (72130-98-4)

Guidance literature:

In ethanol; at 0 - 20 ℃; for 24h;

Reference yield:

isocyanoacetic acid methyl ester (39687-95-1) + N,N-dimethylformamide diethyl diacetal (1188-33-6) → (Z)-1-(dimethylamino)-3-methoxy-N-methylidyne-3-oxoprop-1-en-2-aminium (72130-98-4)

Guidance literature:

In methanol;

upstream raw materials:

isocyanoacetic acid methyl ester

N,N-dimethylformamide diethyl diacetal

dimethyl amine

1-(diethoxymethyl)-1H-imidazole

Downstream raw materials:

methyl 2-(benzamidomethyl)thiazole-4-carboxylate