3-tert-butoxy-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide

Base Information

• Chemical Name: 3-tert-butoxy-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide
• CAS No.: 1005786-54-8
• Molecular Formula: C₂₇H₂₇N₅O₄
• Molecular Weight: 485.542
• Mol file: 1005786-54-8.mol

Synonyms:3-tert-butoxy-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide

Chemical Property of 3-tert-butoxy-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-tert-butoxy-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide

There total 5 articles about 3-tert-butoxy-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

oxalyl dichloride (79-37-8) + N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazine-2-yl]cyclopropanecarboxamide (1005777-50-3) + 3-tert-butoxybenzoic acid (15360-02-8) → 3-tert-butoxy-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide (1005786-54-8)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

ethyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate (1005785-69-2) → 3-tert-butoxy-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide (1005786-54-8)

Guidance literature:

Multi-step reaction with 4 steps

1: barium hydroxide octahydrate / 1-methyl-pyrrolidin-2-one / 12 h / 120 °C

2: N,N-dimethyl acetamide / 16 h / 4 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 150 °C

4: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

With barium hydroxide octahydrate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

DOI:10.1021/jm300126x

Reference yield:

N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide (1005787-88-1) → 3-tert-butoxy-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide (1005786-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 150 °C

2: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

DOI:10.1021/jm300126x

upstream raw materials:

oxalyl dichloride

N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazine-2-yl]cyclopropanecarboxamide

3-tert-butoxybenzoic acid

C₁₁H₁₃ClO₂