2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Base Information

Chemical Name:2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester
CAS No.:114125-40-5
Molecular Formula:C₅₂H₇₂O₁₀SSi
Molecular Weight:917.289
Hs Code.:

2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Synonyms:2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

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Chemical Property of 2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

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Technology Process of 2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

There total 35 articles about 2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114092-31-8
(2S,4S,6S,8R,9S)-2-<(5R)-4-(dimethyl-t-butylsiloxy)>-2-<(5R,2E)-6-hydroxy-3,5-dimethylhex-2-enyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane

: 114125-40-5
2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / CrO₃*2pyr / CH₂Cl₂ / 0.33 h

2: 1.) lithium di-isopropylamide; 2.) 3-dimethylaminopropylamine / 1.) THF, -70 deg C, 20 min; 2.) THF, r.t.

With dipyridine chromium trioxide; 1-amino-3-(dimethylamino)propane; lithium diisopropyl amide; In dichloromethane;

Reference yield:

: 101906-21-2
(2R,4R,6S,8R,9S)-2-<(5R)-(2E)-6-benzyloxy-3,5-dimethyl-hex-2-en-1-yl>-8,9-dimethyl-4-(dimethyl-t-butylsilyloxy)-1,7-dioxaspiro<5.5>undecane

: 114125-40-5
2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / Na / liquid ammonia / 0.5 h / -70 °C

2: 94 percent / CrO₃*2pyr / CH₂Cl₂ / 0.33 h

3: 1.) lithium di-isopropylamide; 2.) 3-dimethylaminopropylamine / 1.) THF, -70 deg C, 20 min; 2.) THF, r.t.

With sodium; dipyridine chromium trioxide; 1-amino-3-(dimethylamino)propane; lithium diisopropyl amide; In dichloromethane; ammonia;

Reference yield:

: 82467-25-2
(+)-(5S,6R)-tetrahydro-5,6-dimethyl-2H-pyran-2-one

: 114125-40-5
2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 16 steps

1: 71 percent / 1.) Et₃O*BF₄; 2.) NaOEt/EtOH / CH₂Cl₂ / 1.) r.t., 24 h; 2.) -70 deg C, 45 min

2: 75 percent / 1.) HCl; 2.) K₂CO₃ / benzene / 1.) 30 min; 2.) 1 h

3: 76 percent / 1.) O₃, pyridine; 2.) Me / CH₂Cl₂; methanol / 1.) -70 deg C; 2.) r.t., 3 h

4: 96 percent / lithium di-isopropylamide / tetrahydrofuran / 0.5 h / -70 °C

5: 35 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.5 h / -70 °C

6: 100 percent / pyridine / 0.5 h / Ambient temperature

7: 40 percent / NaBH₄ / 1,2-dimethoxy-ethane / 3 h / 0 °C

8: Et₃N / dimethylformamide / 2 h / Ambient temperature

9: 1.) LiAlH₄; 2.) 15percent aq. NaOH / diethyl ether / 0.67 h / Ambient temperature

10: 89 percent / pyridinium chlorochromate, 3 Angstroem molecular sieves / CH₂Cl₂ / 0.25 h

11: 1.) BuLi/hexane / 1.) THF, -78 deg C, 45 min; 2.) THF, -78 deg C, then r.t., 1 h

12: NaOH / dioxane / 4 h / Ambient temperature

13: 1.) Mg, 1,2-dibromethane; 2.) tris(acetonylacetonato)iron(III) / 1.) THF, r.t., 30 min, then reflux, 1 h; 2.) THF, r.t, 4 h

14: 98 percent / Na / liquid ammonia / 0.5 h / -70 °C

15: 94 percent / CrO₃*2pyr / CH₂Cl₂ / 0.33 h

16: 1.) lithium di-isopropylamide; 2.) 3-dimethylaminopropylamine / 1.) THF, -70 deg C, 20 min; 2.) THF, r.t.

With pyridine; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; iron(III)-acetylacetonate; ethanol; hexane; 3 A molecular sieve; boron trifluoride diethyl etherate; sodium ethanolate; triethyloxonium fluoroborate; sodium; dipyridine chromium trioxide; potassium carbonate; ozone; magnesium; ethylene dibromide; triethylamine; 1-amino-3-(dimethylamino)propane; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; ammonia; N,N-dimethyl-formamide; benzene;