2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-methanesulfonyloxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Base Information

Chemical Name:2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-methanesulfonyloxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester
CAS No.:114092-33-0
Molecular Formula:C₄₀H₆₆O₉SSi
Molecular Weight:751.11
Hs Code.:

2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-methanesulfonyloxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Synonyms:

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Chemical Property of 2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-methanesulfonyloxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

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Technology Process of 2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-methanesulfonyloxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

There total 38 articles about 2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-methanesulfonyloxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 114092-32-9,114180-42-6
2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-hydroxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

: 114092-33-0,114180-43-7
2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-methanesulfonyloxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at -10 ℃;

Reference yield:

: 114092-31-8
(2S,4S,6S,8R,9S)-2-<(5R)-4-(dimethyl-t-butylsiloxy)>-2-<(5R,2E)-6-hydroxy-3,5-dimethylhex-2-enyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane

: 114092-33-0,114180-43-7
2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-methanesulfonyloxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / CrO₃*2pyr / CH₂Cl₂ / 0.33 h

2: 1.) lithium di-isopropylamide; 2.) 3-dimethylaminopropylamine / 1.) THF, -70 deg C, 20 min; 2.) THF, r.t.

3: 51 percent / 5.65percent sodium amalgam, Na₂HPO₄ / tetrahydrofuran; methanol / 5.5 h / -20 °C

4: Et₃N / CH₂Cl₂ / -10 °C

With disodium hydrogenphosphate; sodium amalgam; dipyridine chromium trioxide; triethylamine; 1-amino-3-(dimethylamino)propane; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 82045-36-1,82109-85-1,101977-92-8
(2S,4S,6S,8R,9S)-4-(dimethyl-t-butylsiloxy)-2-<(5R,2E)-5-formyl-3-methylhex-2-enyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane

: 114092-33-0,114180-43-7
2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-methanesulfonyloxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) lithium di-isopropylamide; 2.) 3-dimethylaminopropylamine / 1.) THF, -70 deg C, 20 min; 2.) THF, r.t.

2: 51 percent / 5.65percent sodium amalgam, Na₂HPO₄ / tetrahydrofuran; methanol / 5.5 h / -20 °C

3: Et₃N / CH₂Cl₂ / -10 °C

With disodium hydrogenphosphate; sodium amalgam; triethylamine; 1-amino-3-(dimethylamino)propane; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;