2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-hydroxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Base Information

Chemical Name:2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-hydroxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester
CAS No.:114092-32-9
Molecular Formula:C₃₉H₆₄O₇Si
Molecular Weight:673.018
Hs Code.:

2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-hydroxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

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Chemical Property of 2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-hydroxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

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Technology Process of 2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-hydroxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

There total 37 articles about 2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-hydroxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 114125-40-5
2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

: 114092-32-9,114180-42-6
2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-hydroxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

: 82045-55-4,82079-59-2,101540-88-9,101977-93-9,114180-41-5
(2S,4S,6S,8R,9S)-4-(dimethyl-t-butylsiloxy)-2-<(5R,2E,6Z,8E)-9-(5-methoxycarbonyl-p-tolyl)-3,5dimethyldeca-2,6,8-trienyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane

: 82045-55-4,82079-59-2,101540-88-9,101977-93-9,114180-41-5
(2S,4S,6S,8R,9S)-4-(dimethyl-t-butylsiloxy)-2-<(5R,2E,6E,8E)-9-(5-methoxycarbonyl-p-tolyl)-3,5dimethyldeca-2,6,8-trienyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In tetrahydrofuran; methanol; at -20 ℃; for 5.5h; Yields of byproduct given;

Reference yield:

: 114092-31-8
(2S,4S,6S,8R,9S)-2-<(5R)-4-(dimethyl-t-butylsiloxy)>-2-<(5R,2E)-6-hydroxy-3,5-dimethylhex-2-enyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane

: 114092-32-9,114180-42-6
2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-hydroxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / CrO₃*2pyr / CH₂Cl₂ / 0.33 h

2: 1.) lithium di-isopropylamide; 2.) 3-dimethylaminopropylamine / 1.) THF, -70 deg C, 20 min; 2.) THF, r.t.

3: 51 percent / 5.65percent sodium amalgam, Na₂HPO₄ / tetrahydrofuran; methanol / 5.5 h / -20 °C

With disodium hydrogenphosphate; sodium amalgam; dipyridine chromium trioxide; 1-amino-3-(dimethylamino)propane; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 82045-36-1,82109-85-1,101977-92-8
(2S,4S,6S,8R,9S)-4-(dimethyl-t-butylsiloxy)-2-<(5R,2E)-5-formyl-3-methylhex-2-enyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane

: 114092-32-9,114180-42-6
2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-hydroxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium di-isopropylamide; 2.) 3-dimethylaminopropylamine / 1.) THF, -70 deg C, 20 min; 2.) THF, r.t.

2: 51 percent / 5.65percent sodium amalgam, Na₂HPO₄ / tetrahydrofuran; methanol / 5.5 h / -20 °C

With disodium hydrogenphosphate; sodium amalgam; 1-amino-3-(dimethylamino)propane; lithium diisopropyl amide; In tetrahydrofuran; methanol;