N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-3-fluorobenzamide

Base Information

• Chemical Name: N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-3-fluorobenzamide
• CAS No.: 1256037-19-0
• Molecular Formula: C₂₃H₂₀FNO₄
• Molecular Weight: 393.415
• Mol file: 1256037-19-0.mol

Synonyms:N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-3-fluorobenzamide

Chemical Property of N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-3-fluorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-3-fluorobenzamide

There total 2 articles about N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-3-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.6%

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone (75665-73-5) + 3-fluorobenzoyl chloride (1711-07-5) → N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-3-fluorobenzamide (1256037-19-0)

Guidance literature:

With triethylamine; In toluene; at 55 - 60 ℃; for 0.5h;

DOI:10.1021/jm100780c

Reference yield: 86.6%

→ N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-3-fluorobenzamide (1256037-19-0)

Guidance literature:

Reference yield: 64.3%

N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-3-fluorobenzamide (1256037-19-0) → 7-benzyloxy-2-(3-fluorophenyl)-6-methoxyquinolin-4-one (1256037-37-2)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; for 20h; Reflux; Inert atmosphere;

DOI:10.1021/jm100780c

upstream raw materials:

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

3-fluorobenzoyl chloride

Downstream raw materials:

7-benzyloxy-2-(3-fluorophenyl)-6-methoxyquinolin-4-one

Refernces

• 1、 Chou, Li-Chen,Tsai, Meng-Tung,Hsu, Mei-Hua,Wang, Sheng-Hung,Way, Tzong-Der,Huang, Chi-Hung,Lin, Hui-Yi,Qian, Keduo,Dong, Yizhou,Lee, Kuo-Hsiung,Huang, Li-Jiau,Kuo, Sheng-Chu. "Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents". experimental part. p. 8047 - 8058. Retrieved 2011/02/25.