75665-73-5

Basic information

• Product Name: 1-[2-Amino-5-methoxy-4-(phenylmethoxy)phenyl]ethanone
• Synonyms: 1-(2-Amino-4-benzyloxy-5-methoxyphenyl)ethanone;1-[2-Amino-5-methoxy-4-(phenylmethoxy)phenyl]ethanone;Ethanone, 1-[2-aMino-5-Methoxy-4-(phenylMethoxy)phenyl]-;1-[2-aMino-4-(benzyloxy)-5-Methoxyphenyl]ethan-1- one
• CAS NO: 75665-73-5
• Molecular Formula: C₁₆H₁₇NO₃
• Molecular Weight: 271.31108
• Mol File: 75665-73-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 135-137℃
• Boiling Point: 450.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.169
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.48±0.10(Predicted)
• CAS DataBase Reference: 1-[2-Amino-5-methoxy-4-(phenylmethoxy)phenyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-Amino-5-methoxy-4-(phenylmethoxy)phenyl]ethanone(75665-73-5)
• EPA Substance Registry System: 1-[2-Amino-5-methoxy-4-(phenylmethoxy)phenyl]ethanone(75665-73-5)

Safety Data

• Hazardous Substances Data: 75665-73-5(Hazardous Substances Data)

Usage

Physical Form

Solid

Uses

1-(2-Amino-4-benzyloxy-5-methoxy-phenyl)-ethanone is a useful research chemical.

Upstream product

• 1835-11-6 4-benzyloxy-3-methoxyacetophenone 
• 100-39-0 benzyl bromide 
• 7646-78-8 tin(IV) chloride 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 75665-88-2 1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone 

Downstream Products

• 205448-29-9 6-methoxy-7-benzyloxy-4(1H)-quinolinone 
• 205448-29-9 7-benzyloxy-4-hydroxy-6-methoxyquinoline 
• 1256037-21-4 N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-4-fluorobenzamide 
• 1256037-19-0 N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-3-fluorobenzamide 
• 1256037-17-8 N-(2-acetyl-5-benzyloxy-4-methoxyphenyl)-2-fluorobenzamide 
• 516526-32-2 4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)aniline 
• 849217-53-4 trifluoromethanesulfonic acid 7-benzyloxy-6-methoxy-quinolin-4-yl ester 

Relevant articles and documents

Heterocyclic compound, preparation method and application thereof

The invention relates to a heterocyclic compound in the technical field of medicines. The compound is represented by a structural general formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, X, Y, Z, Cy1, Cy2, m, n and t have the meanings given in the specification; in addition, the invention also discloses an application of the compound and the pharmaceuticallyacceptable salt thereof in preparation of drugs for treating diseases caused by abnormal high expression of tyrosine kinase, especially application in preparation of drugs for treating and preventingcancers.

A alkyne generation quinoline derivatives and its preparation and use

The invention discloses alkynylquinoline derivatives, and a preparation method and application thereof. The acetylenoquinoline derivatives are alkynylquinoline compounds as shown in a general formula I which is described in the specification and pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof. The invention also provides the preparation method for the derivatives and relates to inhibition activity of the compounds as shown in the formula I to a variety of protein tyrosine kinases (e.g. C-Met and VEGFR). Thus, the compounds can be used as anticancer drugs for treatment of human cancers.

THERAPEUTIC COMPOUNDS AND USES THEREOF

Described herein are compounds of Formula (I) or Formula (VI), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I) or Formula (VI) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating diseases are also provided.