allyl 2-(4-methoxyphenyl)-2-oxoacetate

Base Information

• Chemical Name: allyl 2-(4-methoxyphenyl)-2-oxoacetate
• CAS No.: 1367075-20-4
• Molecular Formula: C₁₂H₁₂O₄
• Molecular Weight: 220.225
• Mol file: 1367075-20-4.mol

Synonyms:allyl 2-(4-methoxyphenyl)-2-oxoacetate

Chemical Property of allyl 2-(4-methoxyphenyl)-2-oxoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of allyl 2-(4-methoxyphenyl)-2-oxoacetate

There total 3 articles about allyl 2-(4-methoxyphenyl)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diallyl oxalate (615-99-6) + 4-methoxyphenyl magnesium bromide (13139-86-1) → allyl 2-(4-methoxyphenyl)-2-oxoacetate (1367075-20-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -80 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.01.133

Reference yield:

4'-Methoxyphenylessigsaeureallylester (15727-84-1) → allyl 2-(4-methoxyphenyl)-2-oxoacetate (1367075-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 23 °C / Inert atmosphere

2: dimethyl sulfoxide / 75 °C

With 4-acetamidobenzenesulfonyl azide; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.1016/j.tetlet.2016.01.020

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → allyl 2-(4-methoxyphenyl)-2-oxoacetate (1367075-20-4)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 23 °C / Inert atmosphere

2: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 23 °C / Inert atmosphere

3: dimethyl sulfoxide / 75 °C

With dmap; 4-acetamidobenzenesulfonyl azide; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile; 1: |Steglich Esterification;

DOI:10.1016/j.tetlet.2016.01.020

upstream raw materials:

diallyl oxalate

4-methoxyphenyl magnesium bromide

4'-Methoxyphenylessigsaeureallylester

4-Methoxyphenylacetic acid

Downstream raw materials:

allyl 2-(4-methoxyphenylimino)-2-(4-methoxyphenyl)acetate