6-(4-chlorophenyl)-3-(4-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Base Information

• Chemical Name: 6-(4-chlorophenyl)-3-(4-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
• CAS No.: 135586-40-2
• Molecular Formula: C₁₄H₈ClN₅S
• Molecular Weight: 313.77
• Mol file: 135586-40-2.mol

Synonyms:6-(4-chlorophenyl)-3-(pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Chemical Property of 6-(4-chlorophenyl)-3-(4-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-chlorophenyl)-3-(4-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

There total 3 articles about 6-(4-chlorophenyl)-3-(4-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol (36209-51-5) + para-chlorobenzoic acid (74-11-3) → 6-(4-chlorophenyl)-3-(pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (135586-40-2)

Guidance literature:

With trichlorophosphate; Reflux;

DOI:10.1016/j.ejmech.2014.08.047

Reference yield:

isoniazid (54-85-3,7640-37-1) → 6-(4-chlorophenyl)-3-(pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (135586-40-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 0 - 20 °C

2: hydrazine hydrate / water / 3 h / Reflux

3: trichlorophosphate / Reflux

With hydrazine hydrate; potassium hydroxide; trichlorophosphate; In ethanol; water;

DOI:10.1080/00304948.2011.582011

Reference yield:

potassium 4-pyridinyldithiocarbazate (61019-32-7) → 6-(4-chlorophenyl)-3-(pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (135586-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / water / 3 h / Reflux

2: trichlorophosphate / Reflux

With hydrazine hydrate; trichlorophosphate; In water;

DOI:10.1080/00304948.2011.582011

upstream raw materials:

4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol

para-chlorobenzoic acid

isoniazid

potassium 4-pyridinyldithiocarbazate