(2S,3S)-methyl-2-hydroxy-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate

Base Information

Chemical Name:(2S,3S)-methyl-2-hydroxy-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate
CAS No.:1034152-44-7
Molecular Formula:C₂₃H₂₃NO₄
Molecular Weight:377.44
Hs Code.:

Synonyms:(2S,3S)-methyl-2-hydroxy-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-methyl-2-hydroxy-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate

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Technology Process of (2S,3S)-methyl-2-hydroxy-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate

There total 9 articles about (2S,3S)-methyl-2-hydroxy-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1034151-91-1
methyl (2S,3S)-2-(9-anthrylmethoxy)-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate

: 1034152-44-7
(2S,3S)-methyl-2-hydroxy-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 50 ℃; optical yield given as %ee;
DOI:10.1021/ja801755z

Reference yield:

: 22979-35-7
Methyl phenyldiazoacetate

: 783-08-4
[4-(benzylideneamino)phenyl]methanol

: 1034152-44-7
(2S,3S)-methyl-2-hydroxy-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate

: methyl-2-hydroxy-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate

: (2R,3S)-methyl-2-hydroxy-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate

Guidance literature:: With dirhodium tetraacetate; (R)‐3,3′‐bis(9‐phenanthryl)‐1,1′‐binaphthalene‐2,2′‐diyl hydrogen phosphate; water; In dichloromethane; at 40 ℃; for 1.5h; stereoselective reaction; Molecular sieve;
DOI:10.1039/c9ob02149c

Reference yield:

: 100-52-7
benzaldehyde

: 1034152-44-7
(2S,3S)-methyl-2-hydroxy-3-(4-methoxyphenylamino)-2,3-diphenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid; magnesium sulfate / methanol / 20 °C

2: dirhodium tetraacetate; (R)‐3,3′‐bis(9‐phenanthryl)‐1,1′‐binaphthalene‐2,2′‐diyl hydrogen phosphate / dichloromethane / 3 h / -20 °C / Molecular sieve; Inert atmosphere

3: sodium iodide; chloro-trimethyl-silane / acetonitrile / 50 °C / Inert atmosphere

With dirhodium tetraacetate; chloro-trimethyl-silane; (R)‐3,3′‐bis(9‐phenanthryl)‐1,1′‐binaphthalene‐2,2′‐diyl hydrogen phosphate; magnesium sulfate; toluene-4-sulfonic acid; sodium iodide; In methanol; dichloromethane; acetonitrile;
DOI:10.1039/c9ob02149c