2-(3-(N,N-dimethylamino)methylphenyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one

Base Information

Chemical Name:2-(3-(N,N-dimethylamino)methylphenyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one
CAS No.:283172-79-2
Molecular Formula:C₂₀H₂₁N₃O
Molecular Weight:319.406
Hs Code.:

Synonyms:2-(3-(N,N-dimethylamino)methylphenyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one

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Chemical Property of 2-(3-(N,N-dimethylamino)methylphenyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one

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Technology Process of 2-(3-(N,N-dimethylamino)methylphenyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one

There total 5 articles about 2-(3-(N,N-dimethylamino)methylphenyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 124-40-3
dimethyl amine

: 283173-73-9
2-(3-formylphenyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one

: 283172-79-2
2-(3-(N,N-dimethylamino)methylphenyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; zinc(II) chloride; In methanol; for 0.5h;
DOI:10.1021/jm020259n

Reference yield:

: 38073-22-2
3,4,5,6-tetrahydro-1H-azepino<5,4,3-cd>indol-6-one

: 283172-79-2
2-(3-(N,N-dimethylamino)methylphenyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / pyridinium tribromide / CH₂Cl₂; tetrahydrofuran / 0 - 20 °C

2: 83 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / 5 h / Heating

3: 87 percent / NaCNBH₃; HCl; ZnCl₂ / methanol / 0.5 h

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium cyanoborohydride; sodium carbonate; pyridinium hydrobromide perbromide; zinc(II) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; 2: Suzuki-type coupling;
DOI:10.1021/jm020259n

Reference yield:

: 87199-16-4
3-Formylphenylboronic acid

: 283172-79-2
2-(3-(N,N-dimethylamino)methylphenyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / 5 h / Heating

2: 87 percent / NaCNBH₃; HCl; ZnCl₂ / methanol / 0.5 h

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium cyanoborohydride; sodium carbonate; zinc(II) chloride; In methanol; ethanol; toluene; 1: Suzuki-type coupling;
DOI:10.1021/jm020259n