1-(4-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE HYDROBROMIDE

Base Information

• Chemical Name: 1-(4-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE HYDROBROMIDE
• CAS No.: 336105-43-2
• Molecular Formula: C₈H₇BrF₃N*ClH
• Molecular Weight: 290.51
• Hs Code.: 2921499090
• Mol file: 336105-43-2.mol

Synonyms:Benzenemethanamine,4-bromo-a-(trifluoromethyl)-,hydrochloride, (aS)-(9CI)

Chemical Property of 1-(4-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE HYDROBROMIDE

Chemical Property:

• PSA: 26.02000
• LogP: 4.66960
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

(1S)-1-(4-Bromophenyl)-2,2,2-trifluoroethan-1-amine hydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE HYDROBROMIDE

There total 15 articles about 1-(4-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE HYDROBROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4'-bromo-2,2,2-trifluoroacetophenone (16184-89-7) → [1-(4-bromophenyl)-2,2,2-trifluoroethyl]amine hydrochloride (842169-72-6,336105-43-2,842169-83-9)

Guidance literature:

4'-bromo-2,2,2-trifluoroacetophenone; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at 20 ℃;

With sodium hydroxide; dimethylsulfide borane complex; In tetrahydrofuran; toluene; at 20 ℃;

With hydrogenchloride; In diethyl ether; toluene; at 20 ℃;

DOI:10.1021/ol047431x

Reference yield: 80.0%

N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide (336105-31-8) → (1S)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine hydrochloride (336105-43-2,842169-83-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

Reference yield:

1-(2,2,2-trifluoro)-1-(4-bromophenyl)ethylimine (842169-80-6) → (1S)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine hydrochloride (336105-43-2,842169-83-9)

Guidance literature:

1-(2,2,2-trifluoro)-1-(4-bromophenyl)ethylimine; With benzo[1,3,2]dioxaborole; (R)-B-butyl-diphenylpyrrolidino-oxazaborolidine; In toluene; at -15 ℃; for 20.5h;

With hydrogenchloride; water; In toluene; at 20 ℃;

upstream raw materials:

4'-bromo-2,2,2-trifluoroacetophenone

1-(2,2,2-trifluoro)-1-(4-bromophenyl)ethylimine

C₁₆H₁₃BrF₃N

N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide

Downstream raw materials:

(1S)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine

N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]methanesulfonamide

N-[(1S)-2,2,2-trifluoro-1-(4-formylphenyl)ethyl]methanesulfonamide

N-[2,2,2-trifluoro-1-(4-hydroxyiminomethylphenyl)ethyl] isobutyramide

Refernces

• 1、 Xu, Jian,Liu, Zhen-Jiang,Yang, Xian-Jin,Wang, Li-Min,Chen, Guan-Long,Liu, Jin-Tao. "One-pot asymmetric synthesis of α-trifluoromethylated amines from α-trifluoromethyl ketones". supporting information; experimental part. p. 8933 - 8937. Retrieved 2011/01/04.
• 2、 -. "Synthesis of alpha fluoroalkyl amines". Page/Page column 5; 6. . Retrieved 2008/06/13.