2-(4-cyano-phenyl)-N-(2-methylamino-5-nitro-phenyl)acetamide

Base Information

• Chemical Name: 2-(4-cyano-phenyl)-N-(2-methylamino-5-nitro-phenyl)acetamide
• CAS No.: 850464-49-2
• Molecular Formula: C₁₆H₁₄N₄O₃
• Molecular Weight: 310.312
• Mol file: 850464-49-2.mol

Synonyms:2-(4-cyano-phenyl)-N-(2-methylamino-5-nitro-phenyl)acetamide

Chemical Property of 2-(4-cyano-phenyl)-N-(2-methylamino-5-nitro-phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-cyano-phenyl)-N-(2-methylamino-5-nitro-phenyl)acetamide

There total 1 articles about 2-(4-cyano-phenyl)-N-(2-methylamino-5-nitro-phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-cyanophenylacetic acid (5462-71-5) + N1-methyl-4-nitrobenzene-1,2-diamine (41939-61-1) → 2-(4-cyano-phenyl)-N-(2-methylamino-5-nitro-phenyl)acetamide (850464-49-2)

Guidance literature:

4-cyanophenylacetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 50 ℃; for 0.5h;

N₁-methyl-4-nitrobenzene-1,2-diamine; In tetrahydrofuran; at 50 ℃; for 2h; Further stages.;

DOI:10.1021/jm0109513

Reference yield: 93.0%

2-(4-cyano-phenyl)-N-(2-methylamino-5-nitro-phenyl)acetamide (850464-49-2) → 4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile (236417-27-9)

Guidance literature:

With acetic acid; for 1h; Heating;

DOI:10.1021/jm0109513

Reference yield:

2-(4-cyano-phenyl)-N-(2-methylamino-5-nitro-phenyl)acetamide (850464-49-2) → 4-(5-amino-1-methyl-1H-benzoimidazol-2-ylmethyl)benzonitrile (236417-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / glacial acetic acid / 1 h / Heating

2: 100 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂

With hydrogen; acetic acid; 10percent Pd/C; In methanol; dichloromethane;

DOI:10.1021/jm0109513

upstream raw materials:

4-cyanophenylacetic acid

N₁-methyl-4-nitrobenzene-1,2-diamine

Downstream raw materials:

4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethyl)benzonitrile

4-(5-amino-1-methyl-1H-benzoimidazol-2-ylmethyl)benzonitrile

N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-N-methyl-benzenesulfonamide

4-[(5-(pyridin-3-yl-sulphonylamino)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzonitrile