(S)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropionaldehyde

Base Information

• Chemical Name: (S)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropionaldehyde
• CAS No.: 1242461-29-5
• Molecular Formula: C₁₄H₁₅NO₃
• Molecular Weight: 245.278
• Mol file: 1242461-29-5.mol

Synonyms:(S)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropionaldehyde

Chemical Property of (S)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropionaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropionaldehyde

There total 3 articles about (S)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-phenyl-maleimide (941-69-5) + isobutyraldehyde (78-84-2) → (S)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropionaldehyde (1242461-29-5)

Guidance literature:

With (R)-3-phenyl-3-aminopropionic acid; potassium hydroxide; In dichloromethane; at 20 ℃; for 24h; enantioselective reaction;

DOI:10.1039/c8nj04274h

Reference yield:

N-phenyl-maleimide (941-69-5) → (S)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropionaldehyde (1242461-29-5) + (R)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropionaldehyde (1258548-30-9)

Guidance literature:

With C₁₃H₁₈N₂O₃; sodium hydroxide; In neat (no solvent); at 20 ℃; for 24h; Reagent/catalyst; Overall yield = 79%; enantioselective reaction;

DOI:10.3390/molecules22081328

Reference yield:

N-phenyl-maleimide (941-69-5) + isobutyraldehyde (78-84-2) → (S)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropionaldehyde (1242461-29-5) + (R)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropionaldehyde (1258548-30-9)

Guidance literature:

With 1-((1R,2R)-2-aminocyclohexyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea; benzoic acid; In acetonitrile; at 20 ℃; for 1h; optical yield given as %ee; enantioselective reaction;

DOI:10.1039/c0ob00154f

upstream raw materials:

N-phenyl-maleimide

isobutyraldehyde

Downstream raw materials:

(S)-methyl 2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropanoate

(S)-2-(4,4-dimethyl-2-oxotetrahydrofuran-3-yl)-N-phenylacetamide

(S)-tert-butyl 2-{[2-((S)-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropanoyl]carbamoyl}-3-methylbutanoate

(S)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-methylpropanoic acid