5-amino-3-(3,4-dichlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:5-amino-3-(3,4-dichlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxamide
CAS No.:1390635-74-1
Molecular Formula:C₁₄H₁₆Cl₂N₄O
Molecular Weight:327.213
Hs Code.:

Synonyms:5-amino-3-(3,4-dichlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxamide

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Chemical Property of 5-amino-3-(3,4-dichlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxamide

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Technology Process of 5-amino-3-(3,4-dichlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxamide

There total 5 articles about 5-amino-3-(3,4-dichlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 32064-67-8
tert-butylhydrazine

: (2Z)-2-cyano-3-(3,4-dichlorophenyl)-3-(methylthio)-2-propenamide

: 1390635-74-1
5-amino-3-(3,4-dichlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxamide

Guidance literature:: With Na⁽¹⁺⁾*C₂H₅O^(1-)*ClH; In ethanol; at 75 ℃; for 2h;
DOI:10.1021/acsmedchemlett.9b00141

Reference yield: 34.0%

: 1390635-64-9
5-amino-3-bromo-1-(tert-butyl)-1H-pyrazole-4-carboxamide

: 151169-75-4
3,4-dichlophenylboronic acid

: 1390635-74-1
5-amino-3-(3,4-dichlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Microwave irradiation;
DOI:10.1021/ol301655f

Reference yield:

: 1390635-65-0
5-amino-3-bromo-1-(t-butyl)-1H-pyrazole-4-carbonitrile

: 1390635-74-1
5-amino-3-(3,4-dichlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol; dimethyl sulfoxide

1.2: 2.5 h / 0 - 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 0.5 h / 120 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; 2.1: Suzuki-Miyaura reaction;
DOI:10.1021/ol301655f