1-(4-fluorophenyl)-4-(1-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-yl)-butane-1-one

Base Information

Chemical Name:1-(4-fluorophenyl)-4-(1-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-yl)-butane-1-one
CAS No.:1229622-13-2
Molecular Formula:C₂₁H₂₄FNO₃
Molecular Weight:357.425
Hs Code.:

Synonyms:1-(4-fluorophenyl)-4-(1-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-yl)-butane-1-one

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Chemical Property of 1-(4-fluorophenyl)-4-(1-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-yl)-butane-1-one

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Technology Process of 1-(4-fluorophenyl)-4-(1-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-yl)-butane-1-one

There total 7 articles about 1-(4-fluorophenyl)-4-(1-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-yl)-butane-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1229622-03-0
7-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol

: 3874-54-2,41167-07-1
4-(4-fluorophenyl)-4-oxo-n-butyl chloride

: 1229622-13-2
1-(4-fluorophenyl)-4-(1-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-yl)-butane-1-one

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile; Inert atmosphere; Reflux;
DOI:10.1002/cmdc.201000005

Reference yield:

: 64880-89-3
N-[(3-methoxyphenyl)ethyl]-4′′-methylbenzenesulfonamide

: 1229622-13-2
1-(4-fluorophenyl)-4-(1-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-yl)-butane-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetone / 20 h / Reflux

2: sodium hydroxide; water / ethanol / 5 h / Reflux

3: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere

4: sodium tetrahydroborate; methanol / 2 h / 20 °C

5: methanol; magnesium / 5 h / Reflux

6: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 72 h / Reflux

With methanol; sodium tetrahydroborate; phosphorus pentoxide; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; sodium hydroxide; In ethanol; 1,2-dichloro-ethane; acetone; acetonitrile;

Reference yield:

: 81593-56-8
[[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetic acid

: 1229622-13-2
1-(4-fluorophenyl)-4-(1-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-yl)-butane-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere

2: sodium tetrahydroborate; methanol / 2 h / 20 °C

3: methanol; magnesium / 5 h / Reflux

4: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 72 h / Reflux

With methanol; sodium tetrahydroborate; phosphorus pentoxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; In 1,2-dichloro-ethane; acetonitrile;