7-(S)-allyl-tert-butoxycarbonylamino-7-(2-pent-4-enyloxyphenylcarbamoyl)heptanoic acid methyl ester

Base Information

Chemical Name:7-(S)-allyl-tert-butoxycarbonylamino-7-(2-pent-4-enyloxyphenylcarbamoyl)heptanoic acid methyl ester
CAS No.:1057664-63-7
Molecular Formula:C₂₈H₄₂N₂O₆
Molecular Weight:502.651
Hs Code.:

Synonyms:7-(S)-allyl-tert-butoxycarbonylamino-7-(2-pent-4-enyloxyphenylcarbamoyl)heptanoic acid methyl ester

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Chemical Property of 7-(S)-allyl-tert-butoxycarbonylamino-7-(2-pent-4-enyloxyphenylcarbamoyl)heptanoic acid methyl ester

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Technology Process of 7-(S)-allyl-tert-butoxycarbonylamino-7-(2-pent-4-enyloxyphenylcarbamoyl)heptanoic acid methyl ester

There total 9 articles about 7-(S)-allyl-tert-butoxycarbonylamino-7-(2-pent-4-enyloxyphenylcarbamoyl)heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1057664-62-6
(S)-2-(allyl-tert-butoxycarbonylamino)octanedioic acid 8-methyl ester

: 107195-50-6
2-(4-Pentenyloxy)anilin

: 1057664-63-7
7-(S)-allyl-tert-butoxycarbonylamino-7-(2-pent-4-enyloxyphenylcarbamoyl)heptanoic acid methyl ester

Guidance literature:: (S)-2-(allyl-tert-butoxycarbonylamino)octanedioic acid 8-methyl ester; With N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; for 0.5h;

2-(4"-Pentenyloxy)anilin; In tetrahydrofuran; for 24 - 36h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1057664-56-8
8-(tert-butyldiphenylsilanyloxy)-7-(R)-hydroxyoctanoic acid methyl ester

: 1057664-63-7
7-(S)-allyl-tert-butoxycarbonylamino-7-(2-pent-4-enyloxyphenylcarbamoyl)heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate / toluene / 24 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h

3.1: dichloromethane / 24 h

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

4.2: 0.17 h / 20 °C

5.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 24 h / 0 - 20 °C

6.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1.5 h / -78 - 20 °C

7.1: Jones reagent / acetone / 0.25 h / 0 °C

8.1: N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / tetrahydrofuran / 0.5 h

8.2: 24 - 36 h

With Jones reagent; oxalyl dichloride; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1057664-57-9
(S)-7-azido-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester

: 1057664-63-7
7-(S)-allyl-tert-butoxycarbonylamino-7-(2-pent-4-enyloxyphenylcarbamoyl)heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h

2.1: dichloromethane / 24 h

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 0.17 h / 20 °C

4.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 24 h / 0 - 20 °C

5.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1.5 h / -78 - 20 °C

6.1: Jones reagent / acetone / 0.25 h / 0 °C

7.1: N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / tetrahydrofuran / 0.5 h

7.2: 24 - 36 h

With Jones reagent; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;