Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate
CAS No.:479630-08-5
Molecular Formula:C15H25NO5
Molecular Weight:299.367
Hs Code.:29333990
DSSTox Substance ID:DTXSID40425071
Nikkaji Number:J1.873.148G
Mol file:479630-08-5.mol

Synonyms:479630-08-5;1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine;tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate;4-(2-Ethoxycarbonyl-acetyl)-piperidine-1-carboxylic acid tert-butyl ester;Ethyl 3-Oxo-3-(1-Boc-4-piperidyl)propanoate;N-BOC-4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE;MFCD04115569;TERT-BUTYL 4-(3-ETHOXY-3-OXOPROPANOYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;4-(2-Ethoxycarbonylacetyl)piperidine-1-carboxylic acid tert-butyl ester;ChemDiv2_002911;SCHEMBL583783;DTXSID40425071;CWTULLANCDLMGK-UHFFFAOYSA-N;HMS1377E07;AKOS001502931;CS-W005286;FB-0733;PB27661;TERT-BUTYL 4-(3-ETHOXY-3-OXOPROPANOYL)TETRAHYDRO-2H-PYRIDINE-1-CARBOXYLATE;SY019634;FT-0657508;EN300-412844;A827408;J-524607;3-Oxo-3-[1-(tert-butoxycarbonyl)piperidine-4-yl]propionic acid ethyl ester;4-(2-ethoxycarbonylacetyl)-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-(3-ethoxy-3-oxo-propanoyl)piperidine-2-carboxylate;N-Boc-4-(2-Ethoxycarbonyl-acetyl)-piperidine

Suppliers and Price of Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl4-(3-Ethoxy-3-oxopropanoyl)piperidine-1-carboxylate
50mg
$ 45.00

SynQuest Laboratories
4-(3-Ethoxy-3-oxopropanoyl)piperidine, N-Boc protected
5 g
$ 416.00

SynQuest Laboratories
4-(3-Ethoxy-3-oxopropanoyl)piperidine, N-Boc protected
1 g
$ 136.00

Matrix Scientific
tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)tetrahydro-1(2H)-pyridinecarboxylate >95%
1g
$ 70.00

Matrix Scientific
tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)tetrahydro-1(2H)-pyridinecarboxylate >95%
5g
$ 235.00

Labseeker
4-(2-ethoxycarbonyl-acetyl)-piperidine-1-carboxylicacidtert-butylester 95
10g
$ 462.00

Crysdot
1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine 95+%
100g
$ 932.00

Crysdot
1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine 95+%
25g
$ 350.00

Chemenu
tert-butyl4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate 97%
10g
$ 216.00

Chemenu
tert-butyl4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate 97%
25g
$ 352.00

Total 48 raw suppliers

Chemical Property of Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

Chemical Property:

Vapor Pressure:3.64E-06mmHg at 25°C
Refractive Index:1.479
Boiling Point:386.1 °C at 760 mmHg
PKA:10.39±0.20(Predicted)
Flash Point:187.3 °C
PSA：72.91000
Density:1.113 g/cm³
LogP:2.09370
Storage Temp.:2-8°C
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:299.17327290
Heavy Atom Count:21
Complexity:391

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl4-(3-Ethoxy-3-oxopropanoyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC(=O)C1CCN(CC1)C(=O)OC(C)(C)C

Technology Process of Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

There total 15 articles about Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2033-24-1
cycl-isopropylidene malonate

: 64-17-5
ethanol

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 479630-08-5
4-(2-ethoxycarbonylacetyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: cycl-isopropylidene malonate; N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane;

ethanol; Heating;
DOI:10.1016/S0040-4039(03)00034-0

Reference yield: 95.0%

: 6148-64-7
ethyl potassium malonate

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 479630-08-5
4-(2-ethoxycarbonylacetyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 4h;

ethyl potassium malonate; With dmap; triethylamine; magnesium chloride; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃;