(2-Amino-5-bromophenyl)methanol

Base Information

• Chemical Name: (2-Amino-5-bromophenyl)methanol
• CAS No.: 20712-12-3
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.051
• Hs Code.: 2922199090
• European Community (EC) Number: 875-573-0
• DSSTox Substance ID: DTXSID301305646
• Nikkaji Number: J1.673.654F
• Mol file: 20712-12-3.mol

Synonyms:(2-AMINO-5-BROMOPHENYL)METHANOL;20712-12-3;226713-43-5;2-AMINO-5-BROMOBENZYL ALCOHOL;Benzenemethanol, 2-amino-5-bromo-;MFCD08234509;(2-amino-5-bromo-phenyl)methanol;(2-Amino-5-bromo-phenyl)-methanol;2-amino-5-bromobenzylalcohol;SCHEMBL789726;5-Bromo-2-aminobenzyl alcohol;2-Amino-5-bromo-benzyl Alcohol;GDCWZYRWKSOYGQ-UHFFFAOYSA-N;(2-amino-5-bromophenyl)-methanol;DTXSID301305646;2-AMINO-5-BROMOBENZENEMETHANOL;AKOS005073745;CS-W005467;MB05459;NB-0807;SB11735;SY028919;2-Amino-5-bromo-benzenemethanol hydrobromide;AM20061028;FT-0647613;FT-0681238;(2-Amino-5-bromophenyl)methanol, AldrichCPR;EN300-141243;A1-01305;J-500626;Z1269160989

Chemical Property of (2-Amino-5-bromophenyl)methanol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.654
• Boiling Point: 329.556 °C at 760 mmHg
• PKA: 14.13±0.10(Predicted)
• Flash Point: 153.11 °C
• PSA: 46.25000
• Density: 1.66 g/cm³
• LogP: 2.10480
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 200.97893
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

97% ^*data from raw suppliers

(2-Amino-5-bromophenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Br)CO)N

Technology Process of (2-Amino-5-bromophenyl)methanol

There total 10 articles about (2-Amino-5-bromophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-Bromo-2-aminobenzoic acid (5794-88-7) → (2-amino-5-bromophenyl)methanol (20712-12-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/cs4000014

Reference yield: 100.0%

dimethyl sulfide borane (13292-87-0) + 5-Bromo-2-aminobenzoic acid (5794-88-7) → (2-amino-5-bromophenyl)methanol (20712-12-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

Reference yield: 96.0%

→ (2-amino-5-bromophenyl)methanol (20712-12-3)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; ethanol; hydrogen; C₃₁H₃₀FeNOP; isopropyl alcohol; lithium tert-butoxide; at 20 ℃; for 12h; under 750.075 Torr;

upstream raw materials:

2-Aminobenzyl alcohol

5-bromo-2-aminobenzoic acid methyl ester

2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one

dimethyl sulfide borane

Downstream raw materials:

N-(4-bromo-2-hydroxymethylphenyl)-2,2,2-trifluoroacetamide

N-(4-bromo-2-hydroxymethyl-phenyl)-acrylamide

5-ethenyl-1-[4-bromo-2-(hydroxymethyl)phenyl]-2-pyrrolidinone

C₁₀H₁₂BrNO₃