2-(3-Aminopropyl)isoindoline-1,3-dione hydrochloride

Base Information

• Chemical Name: 2-(3-Aminopropyl)isoindoline-1,3-dione hydrochloride
• CAS No.: 121821-01-0
• Molecular Formula: C11H12 N2 O2 . Cl H
• Molecular Weight: 240.69
• Hs Code.: 2925190090
• European Community (EC) Number: 802-173-5,808-827-6
• Mol file: 121821-01-0.mol

Synonyms:121821-01-0;2-(3-AMINOPROPYL)ISOINDOLINE-1,3-DIONE HYDROCHLORIDE;N-(3-Amino-propyl)-phthalimide hydrochloride;N-(3-aminopropyl)phthalimide hydrochloride;2-(3-AMINOPROPYL)-1H-ISOINDOLE-1,3(2H)-DIONE, HCL SALT;2-(3-aminopropyl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride;2-(3-aminopropyl)isoindole-1,3-dione;hydrochloride;MFCD00035196;2-(3-aminopropyl)-1H-Isoindole- 1,3(2H)-dione, HCl salt;1H-Isoindole-1,3(2H)-dione, 2-(3-aminopropyl)-, hydrochloride (1:1);2-(3-Aminopropyl)isoindole-1,3(2H)-dione hydrochloride;SCHEMBL18703402;2-(3-Aminopropyl)-1H-isoindole-1,3(2H)-dionehydrochloride;N-(3-Aminopropyl)-phthalimide HCl;AKOS015910386;FS-6038;SB31889;SY198407;2-(3-aminopropyl)isoindole-1,3-dione hcl;CS-0075511;D97311;EN300-209378;A804793;2-(3-AMINOPROPYL)ISOINDOLINE-1,3-DIONE HCL;J-505758;F6170-0130;Z2065464347;2-(3-AMINOPROPYL)ISOINDOLINE-1,3-DIONEHYDROCHLORIDE;N-(3-Amino-propyl)-phthalimide hydrochloride, AldrichCPR

Chemical Property of 2-(3-Aminopropyl)isoindoline-1,3-dione hydrochloride

Chemical Property:

• PSA: 63.40000
• LogP: 2.07160
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 240.0665554
• Heavy Atom Count: 16
• Complexity: 254

Purity/Quality:

97% ^*data from raw suppliers

2-(3-Aminopropyl)isoindoline-1,3-dioneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)CCCN.Cl

Technology Process of 2-(3-Aminopropyl)isoindoline-1,3-dione hydrochloride

There total 2 articles about 2-(3-Aminopropyl)isoindoline-1,3-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,3,4,5-tetrahydroisoindolino<2,1-a>pyrimidin-6-one (22641-00-5) → 2-(3-aminopropyl)isoindoline-1,3-dione hydrochloride (121821-01-0)

Guidance literature:

With hydrogenchloride; In ethanol; at 75 ℃; for 5h;

DOI:10.1246/bcsj.62.198

Reference yield:

1,3-diphthalimidopropane (10513-96-9) → 2-(3-aminopropyl)isoindoline-1,3-dione hydrochloride (121821-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N₂H₄*H₂O / ethanol; dimethylformamide

2: 98 percent / 2M HCl / ethanol / 5 h / 75 °C

With hydrogenchloride; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.62.198

Reference yield: 98.0%

2-(3-aminopropyl)isoindoline-1,3-dione hydrochloride (121821-01-0) + p-toluenesulfonyl chloride (98-59-9) → N-(N3-p-toluenesulfonyl)-3-aminopropylphthalimide (38353-77-4)

Guidance literature:

With pyridine; triethylamine; for 4h; Ambient temperature;

DOI:10.1246/bcsj.62.198

upstream raw materials:

2,3,4,5-tetrahydroisoindolino<2,1-a>pyrimidin-6-one

1,3-diphthalimidopropane

Downstream raw materials:

N-(N³-p-toluenesulfonyl)-3-aminopropylphthalimide

N¹,N¹:N⁷,N⁷-diphthaloyl-4-tosyl-4-azaheptane-1,7-diamine

3-(phthalimido)propyl-p-toluenesulfonate

N-<3-(N-nitroso-p-tolylsulfonamido)propyl>phthalimide

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