10513-96-9

Usage

Chemical Family

Isoindole

Derivative

Phthalimide

Uses

Production of dyes, pigments, and pharmaceuticals

Physical Form

White to off-white crystalline powder

Solubility

Insoluble in water, soluble in organic solvents

Safety Precautions

Potential health hazards and environmental impact, handle with care and in accordance with safety protocols.

Upstream product

• 85-44-9 phthalic anhydride 
• 109-76-2 Trimethylenediamine 
• 5457-29-4 N-(3-iodopropyl)phthalimide 
• 82333-41-3 8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline 

Downstream Products

• 1875-48-5 N-aminophthalamide 
• 109-76-2 Trimethylenediamine 
• 68388-03-4 N,N'-(propane-1,3-diyl)dibenzamide 
• 121821-32-7 4,9,13,18-tetratosyl-N¹,N¹:N²¹,N²¹-diphthaloyl-4,9,13,18-tetraazaheneicosane-1,21-diamine 
• 121821-31-6 N,N'-bis(3-phthalimidopropyl)-N,N'-ditosyl-1,3-propanediamine 
• 121821-26-9 4,8,13,17-tetratosyl-N¹,N¹:N²⁰,N²⁰-diphthaloyl-4,8,13,17-tetraazaeicosane-1,20-diamine 
• 107976-61-4 N,N'-bis(3-phthalimidopropyl)-N,N'-ditosyl-1,4-butanediamine 
• 88597-05-1 N-<3-(N-nitroso-p-tolylsulfonamido)propyl>phthalimide 
• 88597-06-2 3-(phthalimido)propyl-p-toluenesulfonate 

Relevant academic research and scientific papers

Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N-Substituted Phthalimide Derivatives

The unprecedented transformation of a wide range of synthetically appealing phthalimides into amides in a single-step operation has been achieved in high yields and short reaction times using a ruthenium catalyst. Mechanistic studies revealed a unique, homogeneous pathway involving five-membered ring opening and CO2 release with water being the source of protons.

COMPOUNDS AFFECTING GAP JUNCTION ACTIVITY

ThThis invention relates to novel quinoline compounds which affect gap junction activity. Also provided are methods of using such compounds and compositions containing the compounds to treat gap junction disorders.

Thalidomide analogs from diamines: Synthesis and evaluation as inhibitors of TNF-α production

Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83-94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An in vitro investigation of the compounds as inhibitors of the TNF-α production was performed. The inhibition was higher for compounds bearing amino and nitro groups and was modulated by increasing the size of the spacers between the phthalimide groups.