2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid methyl ester
• CAS No.: 1215381-22-8
• Molecular Formula: C₉H₁₂N₂O₃S
• Molecular Weight: 228.272
• Mol file: 1215381-22-8.mol

Synonyms:2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid methyl ester

Chemical Property of 2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid methyl ester

There total 1 articles about 2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + hapalocyclamide (1359827-55-6) + acetic anhydride (108-24-7) → methyl 2-acetamidopropanoate (26629-33-4) + 2-acetylamino-3-mercapto-propionic acid methyl ester (7652-46-2,118398-49-5) + 2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid methyl ester (1215381-22-8) + N-acetylphenylalanine methyl ester (21156-62-7,3618-96-0,62436-70-8) + C18H21N3O4S

Guidance literature:

hapalocyclamide; With hydrogenchloride; In methanol; water; at 100 ℃;

methanol; With hydrogenchloride; at 100 ℃; for 1h;

acetic anhydride; With pyridine; for 24h;

DOI:10.1016/j.tetlet.2011.12.048

Reference yield: 98.0%

2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid methyl ester (1215381-22-8) + benzylamine (100-46-9) → 2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid benzylamide (1215381-40-0)

Guidance literature:

With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In tetrahydrofuran; at 50 ℃;

DOI:10.1039/b918214d

Reference yield: 85.0%

2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid methyl ester (1215381-22-8) + 4-fluoro-2-phenethylamine (1583-88-6) → 2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid [2-(4-fluoro-phenyl)-ethyl]-amide (1215381-34-2)

Guidance literature:

With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In tetrahydrofuran; at 50 ℃;

DOI:10.1039/b918214d

upstream raw materials:

methanol

hapalocyclamide

acetic anhydride

Downstream raw materials:

2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid [2-(4-hydroxy-phenyl)-ethyl]-amide

2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid [2-(4-fluoro-phenyl)-ethyl]-amide

2-(1-acetylamino-ethyl)-thiazole-4-carboxylic acid benzylamide