1-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-5-(4,4-dimethylchroman-6-yl)-N-methoxy-N,2-dimethyl-1H-pyrrole-3-carboxamide

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Chemical Name:1-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-5-(4,4-dimethylchroman-6-yl)-N-methoxy-N,2-dimethyl-1H-pyrrole-3-carboxamide
CAS No.:1392286-07-5
Molecular Formula:C₂₈H₃₄N₄O₅S
Molecular Weight:538.668
Hs Code.:

Synonyms:1-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-5-(4,4-dimethylchroman-6-yl)-N-methoxy-N,2-dimethyl-1H-pyrrole-3-carboxamide

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Chemical Property of 1-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-5-(4,4-dimethylchroman-6-yl)-N-methoxy-N,2-dimethyl-1H-pyrrole-3-carboxamide

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Technology Process of 1-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-5-(4,4-dimethylchroman-6-yl)-N-methoxy-N,2-dimethyl-1H-pyrrole-3-carboxamide

There total 5 articles about 1-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-5-(4,4-dimethylchroman-6-yl)-N-methoxy-N,2-dimethyl-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.6%

: 1392286-06-4
5-(4,4-dimethylchroman-6-yl)-2-methyl-1-(4-sulfamoylphenyl)-1H-pyrrole-3-carboxylic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1392286-07-5
1-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-5-(4,4-dimethylchroman-6-yl)-N-methoxy-N,2-dimethyl-1H-pyrrole-3-carboxamide

Guidance literature:: 5-(4,4-dimethylchroman-6-yl)-2-methyl-1-(4-sulfamoylphenyl)-1H-pyrrole-3-carboxylic acid; N,N-dimethyl-formamide; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 88579-19-5
4,4-Dimethylchroman-6-yl Methyl Ketone

: 1392286-07-5
1-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-5-(4,4-dimethylchroman-6-yl)-N-methoxy-N,2-dimethyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / methanol / 2 h / 10 - 20 °C

2.1: sodium / toluene / 4 h / 0 - 20 °C

3.1: acetic acid / 15 h / 110 °C

4.1: sodium hydroxide; water / ethanol / 3 h / 0 °C / Reflux

4.2: pH 7

5.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.2: 2 h / 0 - 20 °C

With oxalyl dichloride; water; bromine; sodium; sodium hydroxide; In methanol; ethanol; dichloromethane; acetic acid; toluene;

Reference yield:

: 1392286-04-2
ethyl 2-acetyl-4-(4,4-dimethylchroman-6-yl)-4-oxobutanoate

: 1392286-07-5
1-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-5-(4,4-dimethylchroman-6-yl)-N-methoxy-N,2-dimethyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 15 h / 110 °C

2.1: sodium hydroxide; water / ethanol / 3 h / 0 °C / Reflux

2.2: pH 7

3.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.2: 2 h / 0 - 20 °C

With oxalyl dichloride; water; sodium hydroxide; In ethanol; dichloromethane; acetic acid;