(2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

Base Information

Chemical Name:(2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride
CAS No.:1315326-71-6
Molecular Formula:C₃₁H₂₈F₃N₅O₆S*ClH
Molecular Weight:692.115
Hs Code.:

(2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

Synonyms:(2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

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Chemical Property of (2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

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Technology Process of (2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

There total 8 articles about (2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315326-70-5
C₃₆H₃₆F₃N₅O₈S

: 1315326-71-6
(2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

Guidance literature:: With thionyl chloride; In methanol; at 0 - 45 ℃; for 5h;

Reference yield:

: 54802-10-7
3-aminobenzofuran-2-carboxamide

: 1315326-71-6
(2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / tetrahydrofuran / 0 - 20 °C

2.1: potassium tert-butylate / water; tert-butyl alcohol / 70 °C

2.2: pH ~ 2

3.1: trichlorophosphate / 1,4-dioxane / 6.5 h / 0 - 110 °C

3.2: pH 8

4.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 10 - 20 °C

4.2: 1 h / 20 °C

4.3: pH ~ 3

5.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 3 h / 20 °C

6.1: thionyl chloride / methanol / 5 h / 0 - 45 °C

With 4-methyl-morpholine; pyridine; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 1195977-16-2
4-chloro-2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidine

: 1315326-71-6
(2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 10 - 20 °C

1.2: 1 h / 20 °C

1.3: pH ~ 3

2.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 3 h / 20 °C

3.1: thionyl chloride / methanol / 5 h / 0 - 45 °C

With 4-methyl-morpholine; thionyl chloride; benzotriazol-1-ol; HATU; sodium t-butanolate; In methanol; dichloromethane; dimethyl sulfoxide;