(2S,4R)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

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Chemical Name:(2S,4R)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide
CAS No.:1315324-13-0
Molecular Formula:C₄₃H₄₂F₄N₆O₇S
Molecular Weight:862.902
Hs Code.:

(2S,4R)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

Synonyms:(2S,4R)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

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Chemical Property of (2S,4R)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

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Technology Process of (2S,4R)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

There total 9 articles about (2S,4R)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083091-82-0
(S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoic acid

: 1315326-71-6
(2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

: 1315324-13-0
(2S,4R)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; HATU; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 54802-10-7
3-aminobenzofuran-2-carboxamide

: 1315324-13-0
(2S,4R)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / tetrahydrofuran / 0 - 20 °C

2.1: potassium tert-butylate / water; tert-butyl alcohol / 70 °C

2.2: pH ~ 2

3.1: trichlorophosphate / 1,4-dioxane / 6.5 h / 0 - 110 °C

3.2: pH 8

4.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 10 - 20 °C

4.2: 1 h / 20 °C

4.3: pH ~ 3

5.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 3 h / 20 °C

6.1: thionyl chloride / methanol / 5 h / 0 - 45 °C

7.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 24 h / 20 °C

With 4-methyl-morpholine; pyridine; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 611-20-1
salicylonitrile

: 1315324-13-0
(2S,4R)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

1.2: 3 h / 80 °C

2.1: potassium tert-butylate / tert-butyl alcohol / 3 h / 80 °C

3.1: pyridine / tetrahydrofuran / 0 - 20 °C

4.1: potassium tert-butylate / water; tert-butyl alcohol / 70 °C

4.2: pH ~ 2

5.1: trichlorophosphate / 1,4-dioxane / 6.5 h / 0 - 110 °C

5.2: pH 8

6.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 10 - 20 °C

6.2: 1 h / 20 °C

6.3: pH ~ 3

7.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 3 h / 20 °C

8.1: thionyl chloride / methanol / 5 h / 0 - 45 °C

9.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 24 h / 20 °C

With 4-methyl-morpholine; pyridine; thionyl chloride; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;