N-(2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidin-8-yl)picolinamide

Base Information

Chemical Name:N-(2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidin-8-yl)picolinamide
CAS No.:1431647-32-3
Molecular Formula:C₁₉H₁₂F₃N₅O
Molecular Weight:383.332
Hs Code.:

Synonyms:N-(2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidin-8-yl)picolinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidin-8-yl)picolinamide

Chemical Property:

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Technology Process of N-(2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidin-8-yl)picolinamide

There total 5 articles about N-(2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidin-8-yl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 98-98-6
2-Picolinic acid

: 1431654-65-7
2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidin-8-amine

: 1431647-32-3
N-(2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidin-8-yl)picolinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 60 ℃; for 12h;

Reference yield:

: 222292-69-5
ethyl 2-oxo-1,2-dihydroimidazo[1,5-a]pyrimidine-8-carboxylate

: 1431647-32-3
N-(2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidin-8-yl)picolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 1 h / 120 °C

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 100 °C

3: water; potassium hydroxide / methanol / 1 h / Reflux

4: diphenyl phosphoryl azide; triethylamine / water / 20 - 100 °C

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium hydroxide; trichlorophosphate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1250998-26-5
ethyl 2-chloroimidazo[1,5-a]pyrimidine-8-carboxylate

: 1431647-32-3
N-(2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidin-8-yl)picolinamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 100 °C

2: water; potassium hydroxide / methanol / 1 h / Reflux

3: diphenyl phosphoryl azide; triethylamine / water / 20 - 100 °C

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium hydroxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;