C₃₁H₂₁NO₇

Base Information

• Chemical Name: C₃₁H₂₁NO₇
• CAS No.: 1381804-09-6
• Molecular Formula: C₃₁H₂₁NO₇
• Molecular Weight: 519.51
• Mol file: 1381804-09-6.mol

Synonyms:C₃₁H₂₁NO₇

Chemical Property of C₃₁H₂₁NO₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₂₁NO₇

There total 5 articles about C₃₁H₂₁NO₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C6H15N*C31H21NO7 → C31H21NO7 (1381804-09-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In water;

DOI:10.1016/j.bmcl.2012.04.055

Reference yield:

3',6'-bis(2,2-dimethyl-1-oxopropoxy)-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid (192374-17-7) → C31H21NO7 (1381804-09-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 8 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

2.2: pH 2 - 3

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

4.1: porcine liver carboxylesterase / dimethyl sulfoxide / 5 h / 20 °C / pH 8 / aq. buffer; Darkness; Enzymatic reaction

With dmap; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; porcine liver carboxylesterase; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 3.1: Sonogashira coupling;

DOI:10.1016/j.bmcl.2012.04.055

Reference yield:

N-(2''-propynyl)-3',6'-dipivaloyloxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-carboxamide (1381804-22-3) → C31H21NO7 (1381804-09-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

1.2: pH 2 - 3

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

3.1: porcine liver carboxylesterase / dimethyl sulfoxide / 5 h / 20 °C / pH 8 / aq. buffer; Darkness; Enzymatic reaction

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; porcine liver carboxylesterase; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: Sonogashira coupling;

DOI:10.1016/j.bmcl.2012.04.055

upstream raw materials:

N-(2''-propynyl)-3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-carboxamide

N-(2''-propynyl)-3',6'-dipivaloyloxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-carboxamide

2-iodobenzyl alcohol

3',6'-bis(2,2-dimethyl-1-oxopropoxy)-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid