Vvr4774tea

Base Information

Chemical Name:Vvr4774tea
CAS No.:42771-81-3
Molecular Formula:C₂₀H₂₁FO₄
Molecular Weight:344.383
Hs Code.:
UNII:VVR4774TEA
Nikkaji Number:J425.327B

Synonyms:VVR4774TEA;SCHEMBL2138531;1,3-Diethyl 2-(2-fluoro[1,1'-biphenyl]-4-yl)-2-methylpropanedioate;Propanedioic acid, (2-fluoro[1,1'-biphenyl]-4-yl)methyl-, diethyl ester;Propanedioic acid, 2-(2-fluoro[1,1'-biphenyl]-4-yl)-2-methyl-, 1,3-diethyl ester

Suppliers and Price of Vvr4774tea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(2-Fluoro[1,1''-biphenyl]-4-yl)-2,3-dimethylbutanedioicAcidDimethylEster
100mg
$ 595.00

TRC
2-(2-Fluoro[1,1''-biphenyl]-4-yl)-2,3-dimethylbutanedioicAcidDimethylEster
50mg
$ 310.00

TRC
2-(2-Fluoro[1,1''-biphenyl]-4-yl)-2,3-dimethylbutanedioicAcidDimethylEster
25mg
$ 165.00

Total 26 raw suppliers

Chemical Property of Vvr4774tea

Chemical Property:

Boiling Point:413.4±40.0 °C(Predicted)
Density:1.153±0.06 g/cm3(Predicted)
Solubility.:Chloroform, Methanol
XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:344.14238731
Heavy Atom Count:25
Complexity:441

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

2-(2-Fluoro[1,1''-biphenyl]-4-yl)-2,3-dimethylbutanedioicAcidDimethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(C)(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)OCC
Uses 2-(2-Fluoro[1,1''-biphenyl]-4-yl)-2,3-dimethylbutanedioic Acid Dimethyl Ester is an intermediate in the synthesis of 2-(2-Fluoro[1,1''-biphenyl]-4-yl)-2,3-dimethylbutanedioic acid which is an impurity of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic. Flurbiprofen impurity B.

Technology Process of Vvr4774tea

There total 10 articles about Vvr4774tea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 78543-08-5
2-(4-amino-3-fluorophenyl)-2-methylmalonic acid diethyl ester

: 149-73-5
trimethyl orthoformate

: 42771-81-3
diethyl 2-(2-fluorobiphenyl-4-yl)-2-methylmalonate

Guidance literature:: With sodium nitrite; trichloroacetic acid; copper(I) chloride; In benzene;

Reference yield: 88.0%

: 749917-24-6
2-(3-fluoro-4-iodophenyl)-2-methylmalonic acid diethyl ester

: 98-80-6
phenylboronic acid

: 42771-81-3
diethyl 2-(2-fluorobiphenyl-4-yl)-2-methylmalonate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; Reflux; Inert atmosphere;
DOI:10.1002/cmdc.201300490

Reference yield: 80.0%

: diethyl 2-methyl-2-((3'-fluoro-4'-hydrazino)phenyl)malonate

: 71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1
benzene

: 42771-81-3
diethyl 2-(2-fluorobiphenyl-4-yl)-2-methylmalonate

Guidance literature:: trimethyloctylammonium hydrogen sulfate salt; With dihydrogen peroxide; tungsten; In water; at 40 ℃; for 0.5h;

benzene; trimethyloctylammonium hydrogen sulfate salt; In water; at 30 ℃;

diethyl 2-methyl-2-((3'-fluoro-4'-hydrazino)phenyl)malonate; benzene; With dihydrogen peroxide; more than 3 stages;