(R)-[[3-[3-fluoro-4-(4-propyl-1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate

Base Information

Chemical Name:(R)-[[3-[3-fluoro-4-(4-propyl-1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate
CAS No.:268209-52-5
Molecular Formula:C₁₈H₂₃FN₄O₂S
Molecular Weight:378.471
Hs Code.:

Synonyms:(R)-[[3-[3-fluoro-4-(4-propyl-1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-[[3-[3-fluoro-4-(4-propyl-1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate

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Technology Process of (R)-[[3-[3-fluoro-4-(4-propyl-1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate

There total 2 articles about (R)-[[3-[3-fluoro-4-(4-propyl-1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 75-15-0,12122-00-8
carbon disulfide

: 250373-64-9
(S)-5-aminomethyl-3-[3-fluoro-4-(4-propyl-1-piperazinyl)phenyl]oxazolidine-2-one

: 268209-52-5
(R)-[[3-[3-fluoro-4-(4-propyl-1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate

Guidance literature:: With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 4h;
DOI:10.1248/cpb.49.361

Reference yield:

: (R)-5-Azidomethyl-3-[3-fluoro-4-(4-propyl-piperazin-1-yl)-phenyl]-oxazolidin-2-one

: 268209-52-5
(R)-[[3-[3-fluoro-4-(4-propyl-1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]isothiocyanate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / Ph₃P; H₂O / tetrahydrofuran / 17 h / 40 °C

2: 76 percent / Et₃N; ethyl chloroformate / tetrahydrofuran / 4 h / 0 °C

With water; chloroformic acid ethyl ester; triethylamine; triphenylphosphine; In tetrahydrofuran;
DOI:10.1248/cpb.49.361