Cyclopentylphenylacetic acid, (R)-

Base Information

Chemical Name:Cyclopentylphenylacetic acid, (R)-
CAS No.:73495-21-3
Molecular Formula:C₁₃H₁₆O₂
Molecular Weight:204.269
Hs Code.:
UNII:0NWP86561Y
Wikidata:Q27237014

Synonyms:Cyclopentylphenylacetic acid, (R)-;UNII-0NWP86561Y;0NWP86561Y;73495-21-3;(2R)-2-cyclopentyl-2-phenylacetic acid;(R)-cyclopentylphenylacetic acid;(2R)-2-cyclopentyl-2-phenyl-ethanoic acid;A824528;Q27237014;BENZENEACETIC ACID, .ALPHA.-CYCLOPENTYL-, (.ALPHA.R)-

Suppliers and Price of Cyclopentylphenylacetic acid, (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Cyclopentylphenylacetic acid, (R)-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:204.115029749
Heavy Atom Count:15
Complexity:213

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCC(C1)C(C2=CC=CC=C2)C(=O)O
Isomeric SMILES:C1CCC(C1)[C@H](C2=CC=CC=C2)C(=O)O

Technology Process of Cyclopentylphenylacetic acid, (R)-

There total 5 articles about Cyclopentylphenylacetic acid, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 126497-27-6
2-cyclopentylidene-1-phenylacetic acid

: 73495-21-3
(R)-2-cyclopentyl-2-phenylacetic acid

Guidance literature:: With (Sa,S)-[(C₈H₁₂)Ir(P(3,5-(tert-butyl)2C₆H₃)2C₈H₇CC₈H₇C₃NOH₃(benzyl))][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate]; hydrogen; triethylamine; In methanol; at 60 ℃; for 20h; under 4560.31 Torr; enantioselective reaction; Autoclave; Inert atmosphere;
DOI:10.1021/ol401593a

Reference yield:

: 427-49-6
2-cyclopentyl-2-hydroxy-2-phenylacetic acid

: 73495-21-3
(R)-2-cyclopentyl-2-phenylacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 48 h / Reflux

2: triethylamine; hydrogen; (Sa,S)-[(C₈H₁₂)Ir(P(3,5-(tert-butyl)2C₆H₃)2C₈H₇CC₈H₇C₃NOH₃(benzyl))][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate] / methanol / 20 h / 60 °C / 4560.31 Torr / Autoclave; Inert atmosphere

With hydrogenchloride; (Sa,S)-[(C₈H₁₂)Ir(P(3,5-(tert-butyl)2C₆H₃)2C₈H₇CC₈H₇C₃NOH₃(benzyl))][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate]; hydrogen; triethylamine; In methanol; water;
DOI:10.1021/ol401593a

Reference yield:

: 3900-93-4
2-cyclopentyl-2-phenylacetic acid

: 62784-66-1
bis(1-naphthyl)methanol

: 73495-21-3
(R)-2-cyclopentyl-2-phenylacetic acid

: C₃₄H₃₀O₂

: C₃₄H₃₀O₂

: (S)-2-cyclopentyl-2-phenylacetic acid

Guidance literature:: With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; benzoic acid anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 6h; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.tetlet.2010.08.008