1-{3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propyl}-3-(3-trifluoromethyl-phenyl)-urea

Base Information

Chemical Name:1-{3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propyl}-3-(3-trifluoromethyl-phenyl)-urea
CAS No.:1287760-93-3
Molecular Formula:C₂₇H₂₅F₃N₄O₃S
Molecular Weight:542.582
Hs Code.:

Synonyms:1-{3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propyl}-3-(3-trifluoromethyl-phenyl)-urea

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Chemical Property of 1-{3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propyl}-3-(3-trifluoromethyl-phenyl)-urea

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Technology Process of 1-{3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propyl}-3-(3-trifluoromethyl-phenyl)-urea

There total 13 articles about 1-{3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propyl}-3-(3-trifluoromethyl-phenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17852-67-4
4-(methylsulfonyl)phenylhydrazine hydrochloride

: 1287760-93-3
1-{3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propyl}-3-(3-trifluoromethyl-phenyl)-urea

Guidance literature:: Multi-step reaction with 9 steps

1.1: ethanol / 20 °C / Inert atmosphere

1.2: 2 h / Reflux; Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 6 h / 20 °C / Inert atmosphere; Molecular sieve

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

7.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

8.1: hydrazine hydrate / methanol; dichloromethane / 24 h / 20 °C / Inert atmosphere

9.1: N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium hydride; hydrazine hydrate; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil; 4.1: Horner-Wadsworth-Emmons olefination / 7.1: Mitsunobu reaction;
DOI:10.1021/jm2001376

Reference yield:

: 1287761-12-9
C₁₉H₂₁N₃O₂S

: 329-01-1
1-isocyanato-3-trifluoromethyl-benzene

: 1287760-93-3
1-{3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propyl}-3-(3-trifluoromethyl-phenyl)-urea

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm2001376

Reference yield:

: 1287761-07-2
1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole-3-carbaldehyde

: 1287760-93-3
1-{3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propyl}-3-(3-trifluoromethyl-phenyl)-urea

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h

3: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

5: hydrazine hydrate / methanol; dichloromethane / 24 h / 20 °C / Inert atmosphere

6: N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium hydride; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil; 1: Horner-Wadsworth-Emmons olefination / 4: Mitsunobu reaction;
DOI:10.1021/jm2001376