3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propionic acid ethyl ester

Base Information

Chemical Name:3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propionic acid ethyl ester
CAS No.:1287761-09-4
Molecular Formula:C₂₁H₂₂N₂O₄S
Molecular Weight:398.483
Hs Code.:

Synonyms:3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propionic acid ethyl ester

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Chemical Property of 3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propionic acid ethyl ester

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Technology Process of 3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propionic acid ethyl ester

There total 7 articles about 3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1287761-08-3
(E)-3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester

: 1287761-09-4
3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propionic acid ethyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 2h;
DOI:10.1021/jm2001376

Reference yield:

: 17852-67-4
4-(methylsulfonyl)phenylhydrazine hydrochloride

: 1287761-09-4
3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 20 °C / Inert atmosphere

1.2: 2 h / Reflux; Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 6 h / 20 °C / Inert atmosphere; Molecular sieve

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; mineral oil; 4.1: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm2001376

Reference yield:

: 1287761-07-2
1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole-3-carbaldehyde

: 1287761-09-4
3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h

With palladium 10% on activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; ethyl acetate; mineral oil; 1: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm2001376