(E)-3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester

Base Information

Chemical Name:(E)-3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester
CAS No.:1287761-08-3
Molecular Formula:C₂₁H₂₀N₂O₄S
Molecular Weight:396.467
Hs Code.:

Synonyms:(E)-3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester

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Chemical Property of (E)-3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester

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Technology Process of (E)-3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester

There total 6 articles about (E)-3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 1287761-07-2
1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole-3-carbaldehyde

: 1287761-08-3
(E)-3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm2001376

Reference yield:

: 17852-67-4
4-(methylsulfonyl)phenylhydrazine hydrochloride

: 1287761-08-3
(E)-3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 20 °C / Inert atmosphere

1.2: 2 h / Reflux; Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 6 h / 20 °C / Inert atmosphere; Molecular sieve

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; mineral oil; 4.1: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm2001376

Reference yield:

: potassium salt of ethyl 2-hydroxy-4-oxo-4-phenyl-2-butenoate

: 1287761-08-3
(E)-3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 20 °C / Inert atmosphere

1.2: 2 h / Reflux; Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 6 h / 20 °C / Inert atmosphere; Molecular sieve

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; mineral oil; 4.1: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm2001376