3-Chloro-5-nitrobenzotrifluoride

Base Information

• Chemical Name: 3-Chloro-5-nitrobenzotrifluoride
• CAS No.: 401-93-4
• Molecular Formula: C7H3ClF3NO2
• Molecular Weight: 225.555
• Hs Code.: 2904909090
• Mol file: 401-93-4.mol

Synonyms:Toluene,3-chloro-5-nitro-a,a,a-trifluoro- (8CI);3-Chloro-5-nitrobenzotrifluoride;1-Chloro-3-nitro-5-trifluoromethylbenzene;

Chemical Property of 3-Chloro-5-nitrobenzotrifluoride

Chemical Property:

• Vapor Pressure: 0.00373mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 203.4 °C at 760 mmHg
• Flash Point: 76.8 °C
• PSA: 45.82000
• Density: 1.537 g/cm³
• LogP: 3.79020
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chloro-5-nitrobenzotrifluoride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-5-nitrobenzotrifluoride

There total 3 articles about 3-Chloro-5-nitrobenzotrifluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6-nitro-4-(trifluoromethyl)aniline (57729-79-0) → 5-chloro-3-trifluoromethyl-nitrobenzene (401-93-4)

Guidance literature:

With hydrogenchloride; sulfuric acid; sodium nitrite; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol;

Reference yield:

→ 5-chloro-3-trifluoromethyl-nitrobenzene (401-93-4)

Guidance literature:

Reference yield:

3-nitro-5-(trifluoromethyl)-phenylamine (401-94-5) → 5-chloro-3-trifluoromethyl-nitrobenzene (401-93-4)

Guidance literature:

Diazotization_.Behandlung der Diazoniumsalz-Loesung mit CuSO₄ oder CuCl in wss. HCl in der Waerme;

DOI:10.1039/jr9490003016

upstream raw materials:

3-nitro-5-(trifluoromethyl)-phenylamine

2-chloro-6-nitro-4-(trifluoromethyl)aniline

Downstream raw materials:

3-chloro-5-(trifluoromethyl)phenylaniline

α,α,α-Trichlor-3-chlor-5-nitro-toluol

acetic acid-(3-chloro-5-trifluoromethyl-anilide)

Refernces

• 1、 -. "Isoquinoline derivatives with angiogenesis inhibiting activity". . . Retrieved 2008/06/13.