N-[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-succinamic acid

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Chemical Name:N-[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-succinamic acid
CAS No.:1192229-26-7
Molecular Formula:C₃₃H₃₃N₃O₇
Molecular Weight:583.641
Hs Code.:

Synonyms:N-[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-succinamic acid

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Chemical Property of N-[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-succinamic acid

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Technology Process of N-[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-succinamic acid

There total 1 articles about N-[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 108-30-5
succinic acid anhydride

: 124355-25-5
3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine

: 1192229-26-7
N-[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-succinamic acid

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2009.08.018

Reference yield: 78.0%

: 1192228-09-3
5'-amino-N⁽⁶⁾,N⁽⁶⁾-bis(tert-butoxycarbonyl)-5'-deoxy-2',3'-O-isopropylideneadenosine

: 1192229-26-7
N-[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-succinamic acid

: 1374508-81-2
C₅₆H₆₅N₉O₁₃

Guidance literature:: N-[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-succinamic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at -15 - 0 ℃; for 1h;

5'-amino-N⁽⁶⁾,N⁽⁶⁾-bis(tert-butoxycarbonyl)-5'-deoxy-2',3'-O-isopropylideneadenosine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 24h;
DOI:10.1002/chem.201102816