2-(Benzotriazol-1-ylmethyl)-4-phenylthiazole

Base Information

• Chemical Name: 2-(Benzotriazol-1-ylmethyl)-4-phenylthiazole
• CAS No.: 168697-95-8
• Molecular Formula: C₁₆H₁₂N₄S
• Molecular Weight: 292.364
• Mol file: 168697-95-8.mol

Synonyms:2-(Benzotriazol-1-ylmethyl)-4-phenylthiazole

Chemical Property of 2-(Benzotriazol-1-ylmethyl)-4-phenylthiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(Benzotriazol-1-ylmethyl)-4-phenylthiazole

There total 4 articles about 2-(Benzotriazol-1-ylmethyl)-4-phenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

α-bromoacetophenone (70-11-1) + (Benzotriazol-1-yl)thioacetamide (168698-00-8) → 2-(Benzotriazol-1-ylmethyl)-4-phenylthiazole (168697-95-8)

Guidance literature:

In ethanol; 1.) r.t., overnight, 2.) reflux, 4 h;

DOI:10.1021/jo00122a053

Reference yield:

1-(cyanomethyl)benzotriazole (111198-08-4) → 2-(Benzotriazol-1-ylmethyl)-4-phenylthiazole (168697-95-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / K₂CO₃*1.5H₂O, 30percent H₂O₂ / dimethylsulfoxide

2: 83 percent / Lawesson's reagent / tetrahydrofuran / 2 h / Ambient temperature

3: 81 percent / ethanol / 1.) r.t., overnight, 2.) reflux, 4 h

With Lawessons reagent; dihydrogen peroxide; potassium carbonate; In tetrahydrofuran; ethanol; dimethyl sulfoxide;

DOI:10.1021/jo00122a053

Reference yield:

2-(1H-benzo[d][1,2,3]-triazol-1-yl)acetamide (69218-56-0) → 2-(Benzotriazol-1-ylmethyl)-4-phenylthiazole (168697-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Lawesson's reagent / tetrahydrofuran / 2 h / Ambient temperature

2: 81 percent / ethanol / 1.) r.t., overnight, 2.) reflux, 4 h

With Lawessons reagent; In tetrahydrofuran; ethanol;

DOI:10.1021/jo00122a053

upstream raw materials:

α-bromoacetophenone

(Benzotriazol-1-yl)thioacetamide

1,2,3-Benzotriazole

2-(bromomethyl)-4-phenylthiazole

Downstream raw materials:

2-(Benzotriazol-1-yl)-2-(4-phenylthiazol-2-yl)-1-phenylpropane

2-(Benzotriazol-1-yl)-2-(4-phenylthiazol-2-yl)hexane

2-(Benzotriazol-1-yl)-2-(4-phenylthiazol-2-yl)propane

N-Phenyl-4-phenylthiazol-2-acetamide

Refernces

• 1、 Katritzky,Chen,Yang. "1-(cyanomethyl)benzotriazole as a convenient precursor for the synthesis of 2-substituted thiazoles". . p. 5638 - 5642. Retrieved 2007/10/03.