2-(Bromomethyl)-4-phenylthiazole

Base Information

• Chemical Name: 2-(Bromomethyl)-4-phenylthiazole
• CAS No.: 78502-79-1
• Molecular Formula: C10H8 Br N S
• Molecular Weight: 254.15
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID50703877
• Wikidata: Q82636141
• Mol file: 78502-79-1.mol

Synonyms:2-(bromomethyl)-4-phenylthiazole;78502-79-1;2-(BROMOMETHYL)-4-PHENYL-1,3-THIAZOLE;2-Bromomethyl-4-phenylthiazole;SCHEMBL15348483;DTXSID50703877;MYRGZTAFPPWJGI-UHFFFAOYSA-N;MFCD12405586;AKOS016005782;DS-16933;A9870;FT-0688378;O10506;BIS(2-AMINOETHYL)ETHERN,N,N,N-TETRAACETICACID

Chemical Property of 2-(Bromomethyl)-4-phenylthiazole

Chemical Property:

• PSA: 41.13000
• LogP: 3.70500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 252.95608
• Heavy Atom Count: 13
• Complexity: 159

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Bromomethyl)-4-phenylthiazole 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CSC(=N2)CBr

Technology Process of 2-(Bromomethyl)-4-phenylthiazole

There total 7 articles about 2-(Bromomethyl)-4-phenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-hydroxymethyl-4-phenylthiazole (65384-99-8) → 2-(bromomethyl)-4-phenylthiazole (78502-79-1)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 0 - 22 ℃; for 4.2h;

Reference yield: 53.0%

2-methyl-4-phenylthiazole (1826-16-0) → 2-(bromomethyl)-4-phenylthiazole (78502-79-1) + 5-bromo-2-methyl-4-phenylthiazole (78502-81-5) + 2-Dibrommethyl-4-phenylthiazol (78502-80-4)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 10h; Product distribution; Heating;

Reference yield: 19.0%

2-methyl-4-phenylthiazole (1826-16-0) → 2-(bromomethyl)-4-phenylthiazole (78502-79-1)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; Reflux;

upstream raw materials:

2-hydroxymethyl-4-phenylthiazole

2-methyl-4-phenylthiazole

2-ethoxymethyl-4-phenyl-thiazole

α-bromoacetophenone

Downstream raw materials:

2-Methoxy-6-(6-methoxy-4-((4-phenylthiazol-2-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole

2-(Benzotriazol-1-ylmethyl)-4-phenylthiazole

Refernces

• 1、 -. "IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION". Paragraph 00150. . Retrieved 2013/11/18.
• 2、 Krieg, Benno,Mittner, Juergen. "N-Bromosuccinimide Bromination of Substituted Methylthiazoles". . p. 623 - 632. Retrieved 2007/10/02.