6-(2-chlorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Base Information

Chemical Name:6-(2-chlorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS No.:125030-11-7
Molecular Formula:C₁₇H₁₂ClIN₄
Molecular Weight:434.667
Hs Code.:

Synonyms:6-(2-chlorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

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Chemical Property of 6-(2-chlorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Chemical Property:

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Technology Process of 6-(2-chlorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

There total 5 articles about 6-(2-chlorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55500-87-3
5-(2'-chloro-phenyl)-7-iodo-1,3-dihydro-2H-1,4-benzodiazepin-2-one

: 814-49-3
diethyl chlorophosphate

: 1068-57-1
acetic acid hydrazide

: 71-36-3
butan-1-ol

: 6-(2-Chlorophenyl)-B-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

: 125030-11-7
6-(2-chlorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Guidance literature:: In tetrahydrofuran;

Reference yield:

: 125030-09-3
(2-amino-5-iodophenyl)(2-chlorophenyl)methanone

: 125030-11-7
6-(2-chlorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / 10percent aq. Na₂CO₃ / CH₂Cl₂ / 0.5 h / 0 °C

2: liquid ammonia / CH₂Cl₂ / 16 h / Heating

3: HOAc / ethanol / 0.5 h / Heating

With ammonia; sodium carbonate; acetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm00107a048

Reference yield:

: 2-Amino-N-[2-(2-chloro-benzoyl)-4-iodo-phenyl]-acetamide

: 125030-11-7
6-(2-chlorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: HOAc / ethanol / 0.5 h / Heating

With acetic acid; In ethanol;
DOI:10.1021/jm00107a048